Defining the unknowns for cell therapies in Parkinson's disease.
Defining the unknowns for cell therapies in Parkinson's disease.
复制标题
定义帕金森氏病细胞疗法的未知数。
DOI：
10.1242/dmm.049543
复制
发表时间：
2022-10-01
影响因子：
4.3
通讯作者：
Lelos MJ
中科院分区：
文献类型：
--
作者：
Lane EL;Lelos MJ
首次人体临床试验已经开始，以测试帕金森病（PD）患者细胞疗法的安全性和有效性。这种神经修复策略有效的概念证明是基于数十年的临床前研究和使用原代胎儿细胞的临床试验，以及探索更多新型干细胞衍生产品的重要文献。尽管已经探索了几种有效性的测量方法，包括成功地在体外将干细胞分化为多巴胺神经元和在啮齿动物模型中持续缓解运动功能障碍，但关于这种治疗策略的长期临床意义仍然存在许多未知数。在这里，我们考虑一些悬而未决的问题，包括我们的理解之间的相互作用抗帕金森病药物和神经移植，细胞治疗对认知或神经精神症状的PD，神经炎症的作用在治疗过程中的影响和发展的移植诱导的运动障碍。我们确定了目前与需要进一步探索的领域相关的问题，并为更全面地了解这种治疗PD的神经修复策略铺平了道路。摘要：帕金森病的细胞疗法已进入首次人体临床试验。在这里，我们讨论相关的悬而未决的问题，需要考虑广泛采用这种治疗干预之前，仍有待进一步探讨。
First-in-human clinical trials have commenced to test the safety and efficacy of cell therapies for people with Parkinson's disease (PD). Proof of concept that this neural repair strategy is efficacious is based on decades of preclinical studies and clinical trials using primary foetal cells, as well as a significant literature exploring more novel stem cell-derived products. Although several measures of efficacy have been explored, including the successful in vitro differentiation of stem cells to dopamine neurons and consistent alleviation of motor dysfunction in rodent models, many unknowns still remain regarding the long-term clinical implications of this treatment strategy. Here, we consider some of these outstanding questions, including our understanding of the interaction between anti-Parkinsonian medication and the neural transplant, the impact of the cell therapy on cognitive or neuropsychiatric symptoms of PD, the role of neuroinflammation in the therapeutic process and the development of graft-induced dyskinesias. We identify questions that are currently pertinent to the field that require further exploration, and pave the way for a more holistic understanding of this neural repair strategy for treatment of PD. Summary: Cell therapies for Parkinson's disease have entered into first-in-human clinical trials. Here, we discuss pertinent outstanding questions that require consideration before widespread adoption of this therapeutic intervention and remain to be further explored.
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DOI：
10.1002/cne.22037
发表时间：
2009-07-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Steece-Collier K;Soderstrom KE;Collier TJ;Sortwell CE;Maries-Lad E
通讯作者：
Maries-Lad E
影响因子：
5.6
作者：
Elabi OF;Davies JS;Lane EL
通讯作者：
Lane EL
影响因子：
4.8
作者：
Allan, Laura E.;Petit, Geraldine H.;Brundin, Patrik
通讯作者：
Brundin, Patrik
影响因子：
6.1
作者：
Carlsson, T;Winkler, C;Kirik, D
通讯作者：
Kirik, D
影响因子：
11
作者：
Cheesman, AL;Barker, RA;Brooks, DJ
通讯作者：
Brooks, DJ