Cholesterol feeding increases low density lipoprotein synthesis.
Cholesterol feeding increases low density lipoprotein synthesis.
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胆固醇喂养会增加低密度脂蛋白的合成。
DOI：
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发表时间：
1983
影响因子：
15.9
通讯作者：
J. Shepherd
中科院分区：
文献类型：
--
作者：
C. Packard;L. McKinney;K. Carr;J. Shepherd
本研究考察了7名健康志愿者增加饮食胆固醇（每天6个鸡蛋）对低密度脂蛋白代谢的影响。鸡蛋的补充使高密度脂蛋白和低密度脂蛋白胆固醇水平分别提高了18%和40%。低密度脂蛋白的组成没有改变，因此循环颗粒的数量一定增加了。动力学研究表明，这主要是由于脂蛋白合成速率上升了23%。分解代谢也受到影响。天然低密度脂蛋白的分级去除率下降了10% （P < 0.05）。然而，1,2环己二酮处理的脂蛋白清除率保持不变（对照分数清除率[FCR] = 0.188 pools/d，胆固醇饲养FCR = 0.183 pools/d）。因此，低密度脂蛋白分解代谢的减少似乎是由于受体活性的下降。因此，在鸡蛋摄食期间，增加的甾醇负荷（34.2 mumol/kg / d，对照期为27.7 mumol/kg / d, P < 0.02）被引入受体不依赖途径。
This study examines the effects of increased dietary cholesterol (6 eggs/d) on the metabolism of low density lipoproteins in a group of seven healthy volunteers. Egg supplementation raised high density and low density lipoprotein cholesterol levels by 18 and 40%, respectively. The composition of the low density lipoprotein was unaltered and therefore the number of circulating particles must have increased. Kinetic studies indicated that this was due primarily to a 23% rise in the rate of synthesis of the lipoprotein. Catabolism was also affected. The fractional removal rate of native low density lipoprotein fell by 10% (P less than 0.05). However, the clearance of the 1,2 cyclohexanedione-treated lipoprotein remained unchanged (control fractional clearance rate [FCR] = 0.188 pools/d; cholesterol feeding FCR = 0.183 pools/d). Therefore, the reduction in low density lipoprotein catabolism appeared to be due to a fall in receptor activity. Consequently, an increased sterol load (34.2 mumol/kg per d vs. 27.7 mumol/kg per d in the control phase, P less than 0.02) was channelled into the receptor-independent route during egg feeding.
膳食胆固醇和脂肪酸对血浆脂蛋白的影响。
DOI：
10.1172/jci110542
发表时间：
1982
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Schonfeld,G;Patsch,W;Rudel,LL;Nelson,C;Epstein,M;Olson,RE
通讯作者：
Olson,RE
改变膳食脂肪饱和度对人类低密度脂蛋白代谢的影响。
DOI：
10.1152/ajpendo.1981.241.1.e57
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Turner,JD;Le,NA;Brown,WV
通讯作者：
Brown,WV