IGF-1, Inflammation and Retinal Degeneration: A Close Network.
IGF-1, Inflammation and Retinal Degeneration: A Close Network.
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DOI：
10.3389/fnagi.2018.00203
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发表时间：
2018
影响因子：
4.8
通讯作者：
Valverde ÁM
中科院分区：
文献类型：
--
作者：
Arroba AI;Campos-Caro A;Aguilar-Diosdado M;Valverde ÁM
视网膜退行性疾病是一组异质性疾病，包括老年性黄斑变性(AMD)、视网膜色素变性(RP)和糖尿病视网膜病变(DR)。视网膜神经元的进行性变性导致视功能的严重恶化。神经炎症是包括AMD、RP和DR在内的许多视网膜神经退行性疾病的早期特征，小胶质细胞是视网膜免疫防御系统的关键组成部分，在视网膜退行性疾病中被激活。在小胶质细胞中，促炎症/经典激活或抗炎/交替激活表型之间的相互作用是一个复杂的动态过程，在疾病过程中发生的原因是与病理生理条件相关的不同环境信号。在这方面，从促炎反应到抗炎反应的适当过渡是必要的，以对抗视网膜神经变性及其导致视觉功能丧失的后续损害。胰岛素样生长因子-1(IGF-1)在健康或疾病条件下被认为是视网膜中的一种多效性因子，并已被描述在视网膜免疫调节中的几个作用。在这篇综述中，我们提供了关于炎症是视网膜疾病(AMD、RP和RD)的共同特征的最新见解，强调了小胶质细胞、外切体和IGF-1在这一过程中的作用。
Retinal degenerative diseases are a group of heterogeneous diseases that include age-related macular degeneration (AMD), retinitis pigmentosa (RP), and diabetic retinopathy (DR). The progressive degeneration of the retinal neurons results in a severe deterioration of the visual function. Neuroinflammation is an early hallmark of many neurodegenerative disorders of the retina including AMD, RP and DR. Microglial cells, key components of the retinal immune defense system, are activated in retinal degenerative diseases. In the microglia the interplay between the proinflammatory/classically activated or antiinflammatory/alternatively activated phenotypes is a complex dynamic process that occurs during the course of disease due to the different environmental signals related to pathophysiological conditions. In this regard, an adequate transition from the proinflammatory to the anti-inflammatory response is necessary to counteract retinal neurodegeneration and its subsequent damage that leads to the loss of visual function. Insulin like-growth factor-1 (IGF-1) has been considered as a pleiotropic factor in the retina under health or disease conditions and several effects of IGF-1 in retinal immune modulation have been described. In this review, we provide recent insights of inflammation as a common feature of retinal diseases (AMD, RP and RD) highlighting the role of microglia, exosomes and IGF-1 in this process.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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