The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases.
The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases.
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miRNA介导的游离和包封槲皮素对神经系统疾病的潜在神经保护作用。
DOI：
10.3390/nu13041318
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发表时间：
2021-04-16
期刊：
影响因子：
5.9
通讯作者：
Porro C
中科院分区：
文献类型：
--
作者：
Benameur T;Soleti R;Porro C
慢性神经炎症是许多中枢神经系统（CNS）疾病如帕金森病、阿尔茨海默病、多发性硬化症、肌萎缩性侧索硬化症和许多其他疾病的病理状况。神经炎症的特征在于小胶质细胞活化和伴随的促炎细胞因子的产生，导致增加的神经元细胞死亡。减少神经炎症可以通过使用天然化合物来获得，包括已知调节炎症反应的类黄酮。在黄酮类化合物中，槲皮素具有多种药理学应用，包括抗炎、抗肿瘤、抗凋亡和抗血栓形成活性，在体外和体内研究中被广泛证实。本文综述了近年来槲皮素对中枢神经系统小胶质细胞保护作用的研究进展。槲皮素影响microRNA表达的能力代表了在炎症、分化、增殖、凋亡和免疫应答的调节中的有趣技能。此外，为了提高槲皮素的生物利用度和靶向大脑的能力，我们讨论了一种创新的药物递送系统。本文综述了槲皮素在调节神经炎症和预防神经系统疾病中的重要应用。
Chronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant production of pro-inflammatory cytokines leading to an increasing neuronal cell death. The decreased neuroinflammation could be obtained by using natural compounds, including flavonoids known to modulate the inflammatory responses. Among flavonoids, quercetin possess multiple pharmacological applications including anti-inflammatory, antitumoral, antiapoptotic and anti-thrombotic activities, widely demonstrated in both in vitro and in vivo studies. In this review, we describe the recent findings about the neuroprotective action of quercetin by acting with different mechanisms on the microglial cells of CNS. The ability of quercetin to influence microRNA expression represents an interesting skill in the regulation of inflammation, differentiation, proliferation, apoptosis and immune responses. Moreover, in order to enhance quercetin bioavailability and capacity to target the brain, we discuss an innovative drug delivery system. In summary, this review highlighted an important application of quercetin in the modulation of neuroinflammation and prevention of neurological disorders.
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影响因子：
9.3
作者：
Cherry JD;Olschowka JA;O'Banion MK
通讯作者：
O'Banion MK
影响因子：
34.7
作者：
Clarke, Laura E.;Barres, Ben A.
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影响因子：
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作者：
Costa, Lucio G.;Tait, Leah;de Laat, Rian;Dao, Khoi;Giordano, Gennaro;Pellacani, Claudia;Cole, Toby B.;Furlong, Clement E.
通讯作者：
Furlong, Clement E.