Usefulness of cardiovascular magnetic resonance imaging of the superficial femoral artery for screening patients with diabetes mellitus for atherosclerosis.
Usefulness of cardiovascular magnetic resonance imaging of the superficial femoral artery for screening patients with diabetes mellitus for atherosclerosis.
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DOI：
10.1016/j.amjcard.2012.02.048
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发表时间：
2012-07-01
影响因子：
2.8
通讯作者：
Kramer, Christopher M.
中科院分区：
文献类型：
--
作者：
Bourque, Jamieson M.;Schietinger, Brian J.;Kennedy, Jamie L.;Pearce, Emily A.;Christopher, John M.;Taylor, Angela M.;McNamara, Coleen A.;Kramer, Christopher M.
Cardiovascular magnetic resonance (CMR) of the superficial femoral artery (SFA) allows direct visualization of atherosclerotic plaque burden noninvasively. We examined atherosclerosis in 3 groups of patients without a history or symptoms of peripheral arterial disease (PAD) with varying expected burdens: those with diabetes mellitus (DM) and known coronary artery disease (CAD)(n=24); DM and a high prevalence of CAD risk factors (n=20); and controls of similar age without DM or CAD and few CAD risk factors (n=15). We also assessed the diagnostic accuracy of this technique to differentiate between these 3 groups. T1-weighted spin-echo images were used to measure the mean wall thickness (WT) and total wall volume indexed to total vessel volume (IWV). Diagnostic accuracy was assessed by area under the receiver operating characteristic (ROC) curve analysis. Individuals with DM+risk factors and DM+CAD had higher mean WT (1.28mm and 1.37mm) and mean IWV (0.53 and 0.56) compared with controls (mean WT 1.16mm and mean IWV 0.45), all p<0.010. Both mean WT and IWV showed good diagnostic accuracy in discriminating controls from those with DM+CAD (AUCs of 0.85 and 0.87 with p<0.001, respectively), while only IWV discriminated DM+risk factors from controls (AUC=0.82, p<0.001). Neither could discriminate between DM+risk factors and DM+CAD. In conclusion, patients with DM+risk factors and DM+CAD had significantly higher atherosclerotic burden in the SFA on CMR than controls of similar age, with good diagnostic accuracy in differentiating these groups. The high reproducibility and reliability of CMR of the SFA may facilitate improved assessment of atherosclerosis prevalence as well as progression/regression in studies of novel therapies.
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影响因子：
6.4
作者：
Isbell, David C.;Meyer, Craig H.;Kramer, Christopher M.
通讯作者：
Kramer, Christopher M.
影响因子：
--
作者：
Murabito, JM;Evans, JC;Wilson, PWF
通讯作者：
Wilson, PWF
DOI：
10.1161/01.atv.0000168911.78624.b7
发表时间：
2005-07-01
影响因子：
8.7
作者：
Doobay, AV;Anand, SS
通讯作者：
Anand, SS
影响因子：
120.7
作者：
Greenland, P;LaBree, L;Detrano, RC
通讯作者：
Detrano, RC
影响因子：
2.4
作者：
Devine, Patrick J.;Carlson, Daniel W.;Taylor, Allen J.
通讯作者：
Taylor, Allen J.