Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.
Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.
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DOI：
10.1038/s41467-022-28827-2
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发表时间：
2022-03-08
影响因子：
16.6
通讯作者：
Jeong C
中科院分区：
文献类型：
--
作者：
Liu CC;Witonsky D;Gosling A;Lee JH;Ringbauer H;Hagan R;Patel N;Stahl R;Novembre J;Aldenderfer M;Warinner C;Di Rienzo A;Jeong C
如今的藏族人已经在基因和文化上适应了青藏高原的高海拔环境，但关于他们起源的基本问题仍然没有得到解答。最近的考古和遗传学研究表明，在过去的四万年里，高原上出现了早期人口，随后在过去的一万年里，后续群体抵达了这里。在这里，我们获得了来自尼泊尔青藏高原南缘高海拔地区的 33 个古代个体的新全基因组数据，我们发现这些人与当今藏人的关系最为密切。他们的祖先大部分来自与青藏高原东北边缘的新石器时代晚期人群相关的群体，但也拥有来自独特而深厚的旧石器时代欧亚血统的少量遗传成分。与他们的藏族邻居不同，当今居住在高原南部和东部边缘的中海拔地区的非藏族藏缅语族形成了反映独特遗传历史的遗传谱系。最后，古代和现代高地人之间的比较证实了高海拔适应性等位基因的持续积极选择。刘等人。报告了来自喜马拉雅山的 33 个古代个体的全基因组数据，以高分辨率阐明了青藏高原周围藏族和其他藏缅语族群的深层遗传历史。
Present-day Tibetans have adapted both genetically and culturally to the high altitude environment of the Tibetan Plateau, but fundamental questions about their origins remain unanswered. Recent archaeological and genetic research suggests the presence of an early population on the Plateau within the past 40 thousand years, followed by the arrival of subsequent groups within the past 10 thousand years. Here, we obtain new genome-wide data for 33 ancient individuals from high elevation sites on the southern fringe of the Tibetan Plateau in Nepal, who we show are most closely related to present-day Tibetans. They derive most of their ancestry from groups related to Late Neolithic populations at the northeastern edge of the Tibetan Plateau but also harbor a minor genetic component from a distinct and deep Paleolithic Eurasian ancestry. In contrast to their Tibetan neighbors, present-day non-Tibetan Tibeto-Burman speakers living at mid-elevations along the southern and eastern margins of the Plateau form a genetic cline that reflects a distinct genetic history. Finally, a comparison between ancient and present-day highlanders confirms ongoing positive selection of high altitude adaptive alleles. Liu et al. report genome-wide data of 33 ancient individuals from the Himalayas, illuminating the deep genetic history of Tibetans and other Tibeto-Burman-speaking populations around the Tibetan Plateau in fine resolution.
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影响因子：
10.7
作者：
Arciero E;Kraaijenbrink T;Asan;Haber M;Mezzavilla M;Ayub Q;Wang W;Pingcuo Z;Yang H;Wang J;Jobling MA;van Driem G;Xue Y;de Knijff P;Tyler-Smith C
通讯作者：
Tyler-Smith C
青海省黄河流域上游史前人类聚落时空变化及其影响因素
影响因子：
2.8
作者：
Dong, Guanghui;Jia, Xin;An, Chengbang
通讯作者：
An, Chengbang
影响因子：
64.8
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通讯作者：
Reich D
影响因子：
16.6
作者：
Jeong C;Alkorta-Aranburu G;Basnyat B;Neupane M;Witonsky DB;Pritchard JK;Beall CM;Di Rienzo A
通讯作者：
Di Rienzo A
影响因子：
9.2
作者：
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通讯作者：
Lee JJ