Cigarette smoking and cancer mortality risk in Japanese men and women--results from reanalysis of the six-prefecture cohort study data.
Cigarette smoking and cancer mortality risk in Japanese men and women--results from reanalysis of the six-prefecture cohort study data.
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日本男性和女性吸烟与癌症死亡风险——对六县队列研究数据的重新分析结果。
DOI：
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发表时间：
1990
影响因子：
10.4
通讯作者：
T. Hirayama
中科院分区：
文献类型：
--
作者：
S. Akiba;T. Hirayama
1965 年，日本 6 个县 29 个公共卫生区的 265,000 名居民建立了队列，并在 1966 年至 1981 年间进行了跟踪研究。通过使用基于泊松回归模型的生存分析（根据年龄、居住县和职业进行调整），发现吸烟与男女肝癌、胰腺癌和肺癌死亡率之间存在统计学上显着的剂量反应关系。男性口腔癌、食道癌、胃癌、喉癌和膀胱癌；和女性子宫癌。相对风险的大小仅受到居住地或职业调整的轻微影响。使用线性相对风险模型的分析表明，除了线性项之外，还包含每日香烟消费量的二次项，显着提高了模型对男性食道癌和胃癌以及女性胃癌的拟合度。吸烟者胃癌死亡率的性别比例高于不吸烟者。当随访期分为四个 4 年间隔时，人们注意到，在这些时间段内，男性与肺癌相关的相对死亡风险显着增加。
In 1965 a cohort of 265,000 residents of 29 public health districts in six prefectures throughout Japan was established and followed between 1966 and 1981. By using survival analysis based on Poisson regression models adjusted for age, prefecture of residence, and occupation, a statistically significant dose-response relationship between cigarette smoking and mortality rate was found for cancers of the liver, pancreas, and lung in both sexes; cancers of the oral cavity, esophagus, stomach, larynx, and bladder in men; and cancer of the uterus in women. The magnitudes of relative risks were only slightly affected by adjustment for prefecture of residence or occupation. Analysis using linear relative risk models revealed that the inclusion of a quadratic term for the amount of daily cigarette consumption in addition to the linear term improved the fit of the model significantly for cancers of the esophagus and stomach in men and cancer of the stomach in women. The sex ratio of gastric cancer mortality was higher among smokers than among nonsmokers. When the follow-up period was divided into four 4-year intervals, it was noted that the relative mortality risk associated with lung cancer among males increased significantly during these time periods.
影响因子：
11.2
作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson
通讯作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson
吸烟者子宫颈中的致突变粘液。
DOI：
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发表时间：
1986
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Holly,EA;Petrakis,NL;Friend,NF;Sarles,DL;Lee,RE;Flander,LB
通讯作者：
Flander,LB