The Interplay of Exosomes and NK Cells in Cancer Biology.
The Interplay of Exosomes and NK Cells in Cancer Biology.
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DOI：
10.3390/cancers13030473
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发表时间：
2021-01-26
期刊：
影响因子：
5.2
通讯作者：
Melo SA
中科院分区：
文献类型：
--
作者：
Batista IA;Quintas ST;Melo SA
癌症是一种致命的疾病，也是全球第二大常见的死亡原因。据估计，未来几十年癌症发病率和死亡率将上升约50%。目前，免疫疗法已显示出治疗癌症的最佳效果。因此，抗肿瘤免疫反应的研究在癌症研究中具有重要意义。许多因素被描述为参与这一过程。外泌体是细胞外囊泡，它塑造受体细胞的细胞程序并参与癌症进展。我们的综述探讨了外泌体和自然杀伤（NK）细胞之间的联系，癌症进展中可能的后果，以及在这种串扰中识别新的免疫治疗靶点的潜力。自然杀伤（NK）细胞是参与肿瘤监视的先天性淋巴样细胞。这些免疫细胞具有对抗癌症生长和转移的潜力，因此，它们的失调可能导致肿瘤免疫逃逸。最近，外泌体被描述为癌症和NK细胞之间细胞间通讯的介质。细胞外囊泡（EV）的这一亚类的确切作用，它运输遗传和分子物质到受体细胞，在癌症背景下的NK细胞生物学中，仍然是一个悬而未决的问题。一些报告已经证明，肿瘤来源的外泌体（TDE）可以发挥免疫调节活性，包括免疫抑制，从而促进癌症进展。一些报告表明，癌症外泌体和NK细胞之间的相互作用使肿瘤逃避免疫调节。另一方面，肿瘤外泌体也被描述为激活NK细胞。此外，研究表明，NK细胞外泌体可以调节免疫系统，开辟其作为癌症治疗免疫策略的潜力。我们的综述将集中在癌症外泌体对NK细胞的重编程作用，以及NK细胞源性外泌体的免疫抑制潜力。
Cancer is a lethal disease and the second most common cause of death worldwide. It is estimated that the next decades will bring a rise of about 50% in cancer incidence and mortality. At present, immunotherapy has shown the best results for cancer treatment. Because of this, the study of the anti-tumor immune response has gained a significant importance in cancer research. Many are the factors described to be involved in this process. Exosomes are extracellular vesicles that shape the cellular program of the recipient cells and are involved in cancer progression. Our review explores the link between exosomes and natural killer (NK) cells, the possible consequences in cancer progression, and the enclosed potential to identify new immunotherapy targets within this crosstalk. Natural killer (NK) cells are innate lymphoid cells involved in tumor surveillance. These immune cells have the potential to fight cancer growth and metastasis, as such, their deregulation can result in tumor immune escape. Recently exosomes were described as mediators of intercellular communication between cancer and NK cells. The exact role of this subclass of extracellular vesicles (EVs), which transport genetic and molecular material to recipient cells, in NK cell biology in the context of cancer, is still an open question. Several reports have demonstrated that tumor-derived exosomes (TDEs) can exert immunomodulatory activities, including immunosuppression, thus promoting cancer progression. Some reports demonstrate that the interplay between cancer exosomes and NK cells allows tumors to escape immune regulation. On the other hand, tumor exosomes were also described to activate NK cells. Additionally, studies show that NK cell exosomes can modulate the immune system, opening up their potential as an immunotherapeutic strategy for cancer treatment. Our review will focus on the reprogramming effect of cancer exosomes on NK cells, and the immunotherapeutic potential of NK cells-derived exosomes.
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影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
DOI：
10.1016/j.cub.2009.02.023
发表时间：
2009-04-14
期刊：
Current biology : CB
影响因子：
--
作者：
Raulet DH
通讯作者：
Raulet DH
影响因子：
5.5
作者：
Campoli, M;Chang, CC;Ferrone, S
通讯作者：
Ferrone, S
激活的 T 细胞外泌体通过 Fas 信号通路促进肿瘤侵袭
影响因子：
4.4
作者：
Cai, Zhijian;Yang, Fei;Wang, Jianli
通讯作者：
Wang, Jianli
影响因子：
5.5
作者：
André, F;Scharz, NEC;Zitvogel, L
通讯作者：
Zitvogel, L