Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and Applications.
Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and Applications.
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DOI：
10.3390/molecules26144322
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发表时间：
2021-07-16
期刊：
影响因子：
--
通讯作者：
Hettegger H
中科院分区：
文献类型：
--
作者：
Bui CV;Rosenau T;Hettegger H
多糖、寡糖及其衍生物，特别是直链淀粉、纤维素、壳聚糖和β-环糊精，是色谱中手性固定相的手性选择剂，因为它们可以分离多种对映体。通常，这样的CSP通过将多糖和β-环糊精衍生物物理涂覆或化学固定到作为色谱支持物的惰性硅胶载体上来制备。在过去的几年中，新的手性选择剂已经被引入，并且已经开发了制备CSP的进步方法。此外，手性识别机制，发挥了至关重要的作用，在手性分离的研究，得到了更好的阐明。进一步深入了解了市售手性柱材料和/或各自新开发的手性相材料在对映体分离（ES）上的广泛功能性能。本文综述了近年来以多糖和β-环糊精为载体的手性固定相、手性固定相的制备、手性识别机理以及手性分离方法的研究进展，并对2019-2020年这一快速发展的领域进行了展望。
Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellulose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cyclodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.
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影响因子：
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作者：
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在 2,3-和 6-位带有区域选择性不同氨基甲酸酯侧链的直链淀粉衍生物的手性识别能力。
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