Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.
Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.
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DOI：
10.1155/2014/283525
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发表时间：
2014
影响因子：
--
通讯作者：
Su X
中科院分区：
文献类型：
--
作者：
Wu H;Li L;Su X
胆碱能抗炎通路（CAP）是连接免疫系统和神经系统的桥梁，在动物模型中通过靶向不同的免疫、促炎、上皮、内皮、干细胞和祖细胞以及信号通路，在调节炎症中发挥多效性作用。急性肺损伤（acute lung injury，ALI）是一种严重的炎症性疾病。它是致病异质性的，涉及许多细胞和信号通路。本文着重探讨CAP对ALI动物模型、细胞群及信号通路的调节作用。通过比较CAP对全身和肺部炎症的不同作用，我们假设肺副交感神经炎症反射形成，以感知和响应肺部的病原体。针对肺副交感神经炎性反射的形成和功能的工作将扩展我们对迷走神经如何感知，识别和对抗病原体和炎症反应的理解。
Cholinergic anti-inflammatory pathway (CAP) bridges immune and nervous systems and plays pleiotropic roles in modulating inflammation in animal models by targeting different immune, proinflammatory, epithelial, endothelial, stem, and progenitor cells and signaling pathways. Acute lung injury (ALI) is a devastating inflammatory disease. It is pathogenically heterogeneous and involves many cells and signaling pathways. Here, we emphasized the research regarding the modulatory effects of CAP on animal models, cell population, and signaling pathways that involved in the pathogenesis of ALI. By comparing the differential effects of CAP on systemic and pulmonary inflammation, we postulated that a pulmonary parasympathetic inflammatory reflex is formed to sense and respond to pathogens in the lung. Work targeting the formation and function of pulmonary parasympathetic inflammatory reflex would extend our understanding of how vagus nerve senses, recognizes, and fights with pathogens and inflammatory responses.
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