Arsenic exposure and motor function among children in Bangladesh.
Arsenic exposure and motor function among children in Bangladesh.
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DOI：
10.1289/ehp.1103548
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发表时间：
2011-11
影响因子：
10.4
通讯作者：
Graziano JH
中科院分区：
文献类型：
--
作者：
Parvez F;Wasserman GA;Factor-Litvak P;Liu X;Slavkovich V;Siddique AB;Sultana R;Sultana R;Islam T;Levy D;Mey JL;van Geen A;Khan K;Kline J;Ahsan H;Graziano JH
背景：多项研究表明，饮用水中的砷和锰与儿童的智力功能有关。然而，人们对运动功能等其他神经学结果可能存在的关联知之甚少。方法：我们调查了孟加拉304名8-11岁儿童的运动功能与运动功能的关系。我们测量了饮用水、血液、尿液和脚趾甲中砷和锰的浓度。我们使用Bruinks-Oseretsky测试第二版，在四个子量表-精细手动控制(FMC)、手动协调(MC)、身体协调(BC)以及力量和敏捷性-可以用总运动综合评分(TMC)来总结的情况下评估运动功能。结果：转化成对数的AS与TMC[β=-3.6 3；95%可信区间：-6.72，-0.5 4；p<；0.0 1]、FMC(β=-1.6 8；95%CI：-3.19，-0.18；p<；0.0 5)、BC(β=-1.6 1；95%CI：-2.72，-0.5 1；p<；0.0 5；根据性别、就学情况、头围、母亲智力、血浆铁蛋白以及血液中的锰、铅和硒进行调整。AS暴露的其他指标(As、尿As和趾甲As)也与运动功能评分呈负相关，特别是TMC和BC。经平方变换后的血硒与TMC(β=3.5 4；95%CI：1.10，6.0；p<；0.0 1)、FMC(β=1.5 5；95%CI：0.40，2.70；p<；0.005)和MC(β=1.5 7；95%CI：0.60，2.75；p<；0.005)呈正相关。锰暴露与运动功能无明显相关性。结论：我们的研究表明，砷暴露对儿童运动功能有不良影响，而硒对儿童运动功能有保护作用。
Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. Methods: We investigated the associations of WAs and WMn with motor function in 304 children in Bangladesh, 8–11 years of age. We measured As and Mn concentrations in drinking water, blood, urine, and toenails. We assessed motor function with the Bruininks-Oseretsky test, version 2, in four subscales—fine manual control (FMC), manual coordination (MC), body coordination (BC), and strength and agility—which can be summarized with a total motor composite score (TMC). Results: Log-transformed blood As was associated with decreases in TMC [β = –3.63; 95% confidence interval (CI): –6.72, –0.54; p < 0.01], FMC (β = –1.68; 95% CI: –3.19, –0.18; p < 0.05), and BC (β = –1.61; 95% CI: –2.72, –0.51; p < 0.01), with adjustment for sex, school attendance, head circumference, mother’s intelligence, plasma ferritin, and blood Mn, lead, and selenium. Other measures of As exposure (WAs, urinary As, and toenail As) also were inversely associated with motor function scores, particularly TMC and BC. Square-transformed blood selenium was positively associated with TMC (β = 3.54; 95% CI: 1.10, 6.0; p < 0.01), FMC (β = 1.55; 95% CI: 0.40, 2.70; p < 0.005), and MC (β = 1.57; 95% CI: 0.60, 2.75; p < 0.005) in the unadjusted models. Mn exposure was not significantly associated with motor function. Conclusion: Our research demonstrates an adverse association of As exposure and a protective association of Se on motor function in children.
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影响因子：
4.2
作者：
Lei, Cong;Niu, Xiaolin;Wei, Jin
通讯作者：
Wei, Jin
影响因子：
2.1
作者：
Deitz, Jean C;Kartin, Deborah;Kopp, Kay
通讯作者：
Kopp, Kay
影响因子：
8.3
作者：
Calderón, J;Navarro, ME;Díaz-Barriga, F
通讯作者：
Díaz-Barriga, F
DOI：
10.1081/ese-120016887
发表时间：
2003-01-01
影响因子：
2.1
作者：
Mukherjee, SC;Rahman, MM;Chakraborti, D
通讯作者：
Chakraborti, D
影响因子：
4.5
作者：
Csanaky, I;Gregus, Z
通讯作者：
Gregus, Z