Opioid modulation of resting-state anterior cingulate cortex functional connectivity.
Opioid modulation of resting-state anterior cingulate cortex functional connectivity.
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DOI：
10.1177/0269881114548436
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Phan KL
中科院分区：
文献类型：
--
作者：
Gorka SM;Fitzgerald DA;de Wit H;Angstadt M;Phan KL
Evidence suggests that individuals misuse oxycodone, a widely prescribed opioid analgesic, to self-medicate physical and emotional pain. Physical and emotional pain is thought to be represented in the brain by a ‘pain matrix,’ of which the dorsal anterior cingulate cortex (ACC) plays a central role in mediating the affective dimensions of pain. The current study examined oxycodone’s effects on resting-state functional connectivity between the dorsal ACC and regions of the pain matrix (i.e., insula, thalamus, and somatosensory cortices) using functional magnetic resonance imaging (fMRI). In a within-subjects, randomized, double-blind, placebo-controlled, dose-response design, fourteen healthy subjects completed a resting-state scan following ingestion of placebo, 10mg, or 20mg of oxycodone. Functional correlations between the dorsal ACC seed region and the pain matrix were examined and compared across sessions. Results indicated that both the 10mg and 20mg doses of oxycodone reduced functional coupling between the dorsal ACC and bilateral anterior insula and putamen relative to placebo; no differences between the high and low dose of oxycodone were observed. Given that functional interactions between these regions are involved in internal awareness and affective experience of pain or other aversive states, it is possible that oxycodone’s physical and emotional ‘analgesic’ effects are mediated by the disruption of ACC-insula and ACC-putamen connectivity at rest.
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DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
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影响因子：
8.8
作者：
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DOI：
10.1001/archpediatrics.2009.120
发表时间：
2009-08-01
影响因子：
--
作者：
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通讯作者：
Teter, Christian J.
影响因子：
4.2
作者：
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通讯作者：
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影响因子：
14.5
作者：
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通讯作者：
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