The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia.
The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia.
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DOI：
10.3389/fnagi.2023.1149820
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发表时间：
2023
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
瞬时受体电位（TRP）蛋白是多模态阳离子通道超家族的一部分，可被机械、物理和化学刺激激活。在血管内皮中，TRP通道调节两个基本参数：膜电位和细胞内Ca2+浓度[(Ca2+)i]。TRP通道在脑血管内皮中广泛表达，并逐渐成为随着衰老而受损的几种脑微血管功能（如神经血管耦合、内皮功能和血脑屏障通透性）的重要介质。衰老是血管性认知障碍（VCI）最重要的危险因素，预计未来几十年血管性认知障碍患者数量将呈指数级增长。然而，目前还没有预防或治疗方法可以预防VCI的发生和发展。在这篇综述中，我们讨论了内皮TRP通道在大脑多种生理过程中的参与以及与年龄相关的VCI的发病机制，以探索未来潜在的神经保护策略。
Transient receptor potential (TRP) proteins are part of a superfamily of polymodal cation channels that can be activated by mechanical, physical, and chemical stimuli. In the vascular endothelium, TRP channels regulate two fundamental parameters: the membrane potential and the intracellular Ca2+ concentration [(Ca2+)i]. TRP channels are widely expressed in the cerebrovascular endothelium, and are emerging as important mediators of several brain microvascular functions (e.g., neurovascular coupling, endothelial function, and blood–brain barrier permeability), which become impaired with aging. Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the number of individuals affected by VCI is expected to exponentially increase in the coming decades. Yet, there are currently no preventative or therapeutic treatments available against the development and progression of VCI. In this review, we discuss the involvement of endothelial TRP channels in diverse physiological processes in the brain as well as in the pathogenesis of age-related VCI to explore future potential neuroprotective strategies.
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影响因子：
5.6
作者：
Dobreva, Ivelina;Marston, Louise;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
时间限制的喂养（TRF）用于预防与年龄有关的血管认知障碍和痴呆。
影响因子：
13.1
作者：
Balasubramanian P;DelFavero J;Ungvari A;Papp M;Tarantini A;Price N;de Cabo R;Tarantini S
通讯作者：
Tarantini S
DOI：
10.1152/ajpheart.00307.2014
发表时间：
2014-08-01
影响因子：
4.8
作者：
Csiszar, Anna;Gautam, Tripti;Ungvari, Zoltan
通讯作者：
Ungvari, Zoltan
影响因子：
5.6
作者：
Borbely, Eva;Payrits, Maja;Pinter, Erika
通讯作者：
Pinter, Erika
影响因子：
5
作者：
Donato AJ;Morgan RG;Walker AE;Lesniewski LA
通讯作者：
Lesniewski LA