Copy Number Variation and Adaptive Evolutionary Radiations across the African Cichlid phylogeny
Copy Number Variation and Adaptive Evolutionary Radiations across the African Cichlid phylogeny
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非洲慈鲷系统发育中的拷贝数变异和适应性进化辐射
DOI：
10.1145/2975167.2985656
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ritz, Anna
中科院分区：
文献类型：
--
作者：
Menzel, Karl;Renn, Suzy C.;Ritz, Anna
差异率之间的差异很大；有些世系分化得很快，而另一些则没有。当快速分化导致物种形成事件，填补了多个生态位，它被称为适应性辐射。这方面的例子包括加拉帕戈斯雀[2]，非洲鲷[3]，以及在更广泛的层面上寒武纪辐射[4]。基因复制和其他基因组重排事件被认为是这些多样化爆发的原因（或结果）。拷贝数变异通过改变基因剂量效应、创造新的基因功能或允许失去祖先基因[6]的部分功能而与多样化相关。非洲慈鲷适合研究快速分化，因为这些鱼由密切相关的分支组成，其中一些经历了适应性辐射，而另一些没有。这样就可以在多个辐射事件中比较大量的物种。观察许多慈鲷物种的拷贝数变化和这种变化的维持，将使我们开始推断进化树中基因组重排事件发生的地点和时间，以及它们可能产生的影响。这将增加我们对慈鲷和其他快速多样化物种的拷贝数模式的理解。以往对慈鲷适应性辐射的研究主要是利用阵列[5]和全基因组测序[1]来研究拷贝数变异。这两种方法都集中研究了慈鲷谱系中的五个物种。高深度测序是昂贵的，这使得对大量个体进行测序变得困难。以阵列为基础的实验更便宜，对许多个体的研究更可行。然而，特定的阵列可能无法用于非模式生物，如慈鲷。
There are wide ranges of variation between rates of divergence; some lineages diverge very quickly while others do not. When rapid divergence leads to speciation events that fill multiple niches, it is termed adaptive radiation. Examples of this include the Galapagos finches [2], the African cichlids [3], and at a broader level the Cambrian radiation [4]. Gene duplication and other genome rearrangement events have been proposed to contribute to (or result from) these explosions of diversification. Copy number variation is associated with diversification by changing gene dosage effects, creating novel gene functions, or by allowing for loss of part of the function of the ancestral gene [6]. African cichlids lend themselves towards research in rapid divergence because these fish consist of closely related clades, some of which have undergone adaptive radiation while others have not. This allows for a large number species to be compared across multiple radiation events. Looking at copy number variation and maintenance of this variation across many cichlid species will allow us begin to infer where and when genome rearrangement events occurred in the evolutionary tree and what effect they might have had. This will increase our understanding of copy number patterns in cichlids as well as other rapidly diversifying species. Previous studies of adaptive radiation in cichlids have used arrays [5] as well as whole genome sequencing [1] to study copy number variation. Both approaches focused on five species within the cichlid lineage. High depth sequencing is expensive which makes it difficult to sequence a large number of individuals. Array-based experiments are cheaper and more feasible for studies with many individuals. However, specific arrays may not be available for non-model organisms such as cichlids.
DOI：
10.1111/j.1439-0469.1977.tb00535.x
发表时间：
2009
影响因子：
1.9
作者：
G. Fryer
通讯作者：
G. Fryer
精彩生活：伯吉斯页岩和历史的本质，斯蒂芬·杰伊·古尔德。
影响因子：
2.5
作者：
J. Hailman
通讯作者：
J. Hailman