The multiple roles of salt-inducible kinases in regulating physiology.
The multiple roles of salt-inducible kinases in regulating physiology.
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盐诱导激酶在调节生理学中的多重作用。
DOI：
10.1152/physrev.00023.2022
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发表时间：
2023-07-01
影响因子：
33.6
通讯作者：
Foster, Russell G.
中科院分区：
文献类型：
--
作者：
Jagannath, Aarti;Taylor, Lewis;Ru, Yining;Wakaf, Zeinab;Akpobaro, Kayomavua;Vasudevan, Sridhar;Foster, Russell G.
盐诱导激酶（SIKs）由三个同源丝氨酸-苏氨酸激酶家族组成，最初被描述为它们在钠传感中的作用，但后来被证明可以调节生理学的多个方面。这些激酶在响应细胞外信号时被激活或失活，这些信号是由细胞表面受体介导的，并继续磷酸化多个靶标，包括转录辅助因子CRTC1-3和IIa类组蛋白去乙酰化酶（hdac）。因此，SIK家族传递有关细胞环境的信号，以对转录和转录后过程进行重编程。通过这种方式，SIKs已被证明可以调节进食/禁食、细胞分裂和肿瘤发生、炎症、免疫反应以及最近的睡眠和昼夜节律的代谢反应。睡眠和昼夜节律是生理的主要调节者，对环境光和生理信号（如睡眠需求）的调节极为敏感。盐诱导激酶已被证明是这两个过程的分子调控的中心。在这里，我们总结了SIKs控制这些不同生理领域的分子机制，并强调了与睡眠/昼夜节律控制的机制重叠。
Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine kinases, were first described for their role in sodium sensing but have since been shown to regulate multiple aspects of physiology. These kinases are activated or deactivated in response to extracellular signals that are cell surface receptor mediated and go on to phosphorylate multiple targets including the transcription cofactors CRTC1–3 and the class IIa histone deacetylases (HDACs). Thus, the SIK family conveys signals about the cellular environment to reprogram transcriptional and posttranscriptional processes in response. In this manner, SIKs have been shown to regulate metabolic responses to feeding/fasting, cell division and oncogenesis, inflammation, immune responses, and most recently, sleep and circadian rhythms. Sleep and circadian rhythms are master regulators of physiology and are exquisitely sensitive to regulation by environmental light and physiological signals such as the need for sleep. Salt-inducible kinases have been shown to be central to the molecular regulation of both these processes. Here, we summarize the molecular mechanisms by which SIKs control these different domains of physiology and highlight where there is mechanistic overlap with sleep/circadian rhythm control.
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影响因子：
8
作者：
Cante-Barrett, Kirsten;Meijer, Mariska T.;Cordo, Valentina;Hagelaar, Rico;Yang, Wentao;Yu, Jiyang;Smits, Willem K.;Nulle, Marloes E.;Jansen, Joris P.;Pieters, Rob;Yang, Jun J.;Haigh, Jody J.;Goossens, Steven;Meijerink, Jules P. P.
通讯作者：
Meijerink, Jules P. P.
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影响因子：
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作者：
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影响因子：
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通讯作者：
Bast RC Jr
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影响因子：
8.8
作者：
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R
通讯作者：
Wooster, R
影响因子：
56.9
作者：
Bruening, Franziska;Noya, Sara B.;Robles, Maria S.
通讯作者：
Robles, Maria S.