GB Virus C epidemiology in denmark: Different routes of transmission in children and low‐ and high‐risk adults
GB Virus C epidemiology in denmark: Different routes of transmission in children and low‐ and high‐risk adults
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丹麦 GB 病毒 C 流行病学：儿童以及低风险和高风险成人的不同传播途径
DOI：
10.1002/jmv.10359
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发表时间：
2003
影响因子：
12.7
通讯作者：
J. Georgsen
中科院分区：
文献类型：
--
作者：
P. Christensen;N. Fisker;L. Mygind;H. Krarup;N. Wedderkopp;K. Varming;J. Georgsen
With the demonstration of an effect of GBV‐C infection on the outcome of HIV infection, it has become important to understand the epidemiology of GBV‐C. The purpose of this study was to determine the prevalence in high‐ and low‐risk populations. The following populations were tested: school children, 9 and 15 years of age (n = 901), blood donors (n = 5,203), hospital employees (n = 1,432), and prisoners and injecting drug users (n = 447). In‐house RT‐PCR for GBV‐CRNA was used together with a commercial ELISA for anti‐E2 (Boehringer, Germany). In addition, questionnaires for risk factors for transmission and serological tests for HIV and hepatitis were applied. The overall prevalence of GBV‐CRNA was 1.4% among children, 2.2% among blood donors, 2.2% among hospital employees, 12.5% among non‐injecting prisoners, and 34.9% among drug injectors. Correspondingly anti‐E2 was found in 0.3%, 12.3%, 25.0%, and 42.7%. Among hospital employees, independent risk factors for GBV‐C were professions with blood exposure and sexual risk partners. Among prisoners and drug users, injecting and a sexual risk index were associated independently with GBV‐C. Based on these results, the following hypothesis is suggested: GBV‐C is transmitted frequently at birth or early childhood and this leads to chronic infection in most cases. Sexual transmission is the most important route of transmission in the adult population but this infection is usually transient. Blood borne transmission plays a role among health care workers and injecting drug users and GBV‐C should be further evaluated as a surrogate marker for professional blood exposure. J. Med. Virol. 70:156–162, 2003. © 2003 Wiley‐Liss, Inc.
GB 丙型肝炎病毒/庚型肝炎病毒感染在美国儿童和年轻人中很常见。
DOI：
10.1086/313702
发表时间：
2000
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Handa,A;Jubran,RF;Dickstein,B;Boylan,A;Luban,NL;Young,NS;Brown,KE
通讯作者：
Brown,KE
注射吸毒者中庚型肝炎病毒感染的持续性和临床意义。
DOI：
10.1086/514078
发表时间：
1997
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Thomas,DL;Nakatsuji,Y;Shih,JW;Alter,HJ;Nelson,KE;Astemborski,JA;Lyles,CM;Vlahov,D
通讯作者：
Vlahov,D
影响因子：
158.5
作者：
Xiang, JH;W端nschmann, S;Stapleton, JT
通讯作者：
Stapleton, JT