Persistence and clinical significance of hepatitis G virus infections in injecting drug users.
Persistence and clinical significance of hepatitis G virus infections in injecting drug users.
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注射吸毒者中庚型肝炎病毒感染的持续性和临床意义。
DOI：
10.1086/514078
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Vlahov,D
中科院分区：
文献类型：
--
作者：
Thomas,DL;Nakatsuji,Y;Shih,JW;Alter,HJ;Nelson,KE;Astemborski,JA;Lyles,CM;Vlahov,D
To assess the persistence of hepatitis G virus (HGV) infection and its association with liver disease, HGV RNA was assessed in the most recent serum sample for 246 long-term injecting drug users (IDUs) and in prior specimens for those found HGV RNA-positive. HGV RNA was detected at the most recent visit in 38 (15.4%). For 31 (82%), HGV RNA was also found at all prior visits occurring a median of 6.1 years earlier. HGV-positive IDUs were younger and had fewer years of drug use, suggesting that HGV RNA had previously been cleared. Serial samples from 29 short-term IDUs were then assessed. HGV RNA was detected in 9 (31%) of 29 short-term IDUs, and 5 (56%) of the 9 HGV infections cleared. No differences were detected in serum levels of liver-related enzymes among HGV RNA-positive and -negative participants (P> .20). HGV infection is not associated with hepatic inflammation. HGV clearance occurs after many acute infections but uncommonly in persons who remain RNA-positive years after exposure.
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