A new translation and reader's guide to the first detailed description of the first wave of spermatogenesis in the mouse.
A new translation and reader's guide to the first detailed description of the first wave of spermatogenesis in the mouse.
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DOI：
10.1002/mrd.23519
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发表时间：
2021-07
影响因子：
2.5
通讯作者：
Geyer CB
中科院分区：
文献类型：
--
作者：
Jones SL;Styles J;Geyer CB
雄性生殖力的基础是精原细胞，它在哺乳动物出生后的睾丸中形成。精原细胞的发育起源直到20世纪中叶才被弄清楚，在此之前，研究不同脊椎动物模式生物（如小鼠、鸟类、两栖动物）的科学家们一直在争论精原细胞是起源于生殖细胞还是支持细胞。1957年，伊夫·克莱蒙特（Yves Clermont）和伯纳德·佩雷（Bernard Perey）进行了一项具有里程碑意义的研究（Clermont & Perey，1957），至少在啮齿动物中，这一争论得到了解决。他们对胎儿和出生后大鼠睾丸中的生殖细胞和体细胞群进行了定量组织学分析，并得出结论：精原细胞分裂形成精原细胞，而支持细胞群在终末分化前一直扩增到出生后第15天，以支持持续的精子发生。我们对Friedrich Hermann博士1889年的手稿产生了兴趣，该手稿题为“小鼠睾丸的胎后组织发生，青春期基于上述Clermont-Perey研究（Clermont & Perey，1957）中的参考。他们说，“赫尔曼简要地从组织学角度描述了[生精]小管的发育，以支持他的观点[精原细胞产生精原细胞]"。如果属实，那么赫尔曼的手稿描述了最早的研究之一，为宇宙的连续性提供了证据。
The foundation for male fertility is provided by spermatogonia, which form in the postnatal mammalian testis. The developmental origin of spermatogonia was unclear until the midtwentieth century–before then, there was a debate among scientists studying different vertebrate model organisms (eg mice, birds, amphibians) whether spermatogonia originated from prospermatogonia (also termed gonocytes) or from somatic Sertoli cells. This debate was settled, at least in rodents, in a landmark study in 1957 by Yves Clermont and Bernard Perey (Clermont & Perey, 1957). They performed quantitative histological analyses of the germ and somatic cell populations in testes from fetal and postnatal rats and concluded that prospermatogonia divide to form spermatogonia, while the Sertoli cell population expands until postnatal day 15 before terminally differentiating to support ongoing spermatogenesis.We became interested in this 1889 manuscript by Dr. Friedrich Hermann entitled Postfetal Histiogenesis of the Mouse Testicle up to Puberty based on a reference in the aforementioned Clermont-Perey study (Clermont & Perey, 1957). They stated,“Hermann gave a brief histological account of the development of the [seminiferous] tubule in support of his opinion [that prospermatogonia produce spermatogonia]”. If true, then Hermann’s manuscript describes one of the earliest studies providing evidence for the continuity of the
影响因子：
--
作者：
CLERMONT, Y;PEREY, B
通讯作者：
PEREY, B