Long-lived ¹H nuclear spin singlet in dimethyl maleate revealed by addition of thiols.
Long-lived ¹H nuclear spin singlet in dimethyl maleate revealed by addition of thiols.
复制标题
通过添加硫醇揭示了马来酸二甲酯中的长寿命 1H 核自旋单线态。
作者：
Yuning Zhang;Pei Che Soon;A. Jerschow;J. Canary
核磁共振（NMR）波谱和磁共振成像（MRI）已成为许多研究领域的重要技术。这些方法的一个主要限制是灵敏度相对较低，最近已通过超极化解决了这一问题。然而，一旦对分子施加超极化，磁化强度通常会在相对较短的时间内衰减。单线态与环境隔离良好，因此具有较长的寿命。我们在此描述了使用硫醇缀合物加成读出马来酸二甲酯中超极化长寿命状态的模型反应。这种类型的反应可以通过硫醇的灵敏检测来监测氧化应激或缺氧。类似的反应可用于生物传感器或利用分子转换的测定。在该系统中，[D4]MeOH 中 (1)H 自旋的单线态寿命约为 4.7 min。
Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) have become important techniques in many research areas. One major limitation is the relatively low sensitivity of these methods, which recently has been addressed by hyperpolarization. However, once hyperpolarization is imparted on a molecule, the magnetization typically decays within relatively short times. Singlet states are well isolated from the environment, such that they acquire long lifetimes. We describe herein a model reaction for read-out of a hyperpolarized long-lived state in dimethyl maleate using thiol conjugate addition. This type of reaction could lend itself to monitoring oxidative stress or hypoxia by sensitive detection of thiols. Similar reactions could be used in biosensors or assays that exploit molecular switching. Singlet lifetimes of about 4.7 min for (1)H spins in [D4]MeOH are seen in this system.
影响因子：
21.8
作者：
通讯作者：
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影响因子：
18.3
作者：
Major, Jody L.;Meade, Thomas J.
通讯作者：
Meade, Thomas J.