Postoperative changes in high mobility group box 1 levels after colorectal cancer surgery.
Postoperative changes in high mobility group box 1 levels after colorectal cancer surgery.
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DOI：
10.1177/0300060516665455
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Takeuchi M
中科院分区：
文献类型：
--
作者：
Satoh M;Kotani K;Yamada S;Koinuma K;Horie H;Takeuchi M
探讨高迁移率族蛋白1（HMGB1）作为结直肠癌（CRC）手术后手术进程标志物的潜在用途。接受开放性结直肠手术的晚期CRC患者未发生术后并发症，入选本研究。分别于术前、术后1d、1周、3周采集血样，测定白色细胞计数、血清C反应蛋白、血清淀粉样蛋白A和高迁移率族蛋白1（HMGB1）。分析了21例患者的数据。HMGB1水平在手术过程中发生了显著变化，从术前的中位数6.8 ng/ml增加到术后1天的12.1 ng/ml，然后在术后1周下降到8.1 ng/ml，术后3周下降到4.0 ng/ml。这些变化与其他标志物中观察到的变化相似，但不完全相关。血清HMGB1可能是一个潜在的标志物，以监测手术过程中的患者接受手术的CRC，虽然进一步的研究是必要的，然后才可以引入到常规的临床实践。
To investigate the potential use of high mobility group box 1 (HMGB1) as a marker for the surgical course following surgery for colorectal cancer (CRC). Patients with advanced CRC undergoing open colorectal surgery who did not develop postsurgical complications were enrolled in the study. Blood samples were taken preoperatively and at 1 day, 1 week and 3 weeks after surgery for the measurement of the white blood cell count, serum C-reactive protein, serum amyloid A and HMGB1. Data from 21 patients were analysed. HMGB1 levels changed significantly during the surgical course, increasing from a preoperative median of 6.8 ng/ml to 12.1 ng/ml at 1 day postoperatively, and then decreasing to 8.1 ng/ml at 1 week postoperatively and 4.0 ng/ml at 3 weeks postoperatively. These changes were similar to but were not completely correlated with the changes seen in the other markers. Serum HMGB1 may be a potential marker to monitor the surgical course in patients undergoing surgery for CRC, although further studies are warranted before it can be introduced into routine clinical practice.
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影响因子：
64.8
作者：
Scaffidi, P;Misteli, T;Bianchi, ME
通讯作者：
Bianchi, ME
影响因子：
38.9
作者：
Karlsson, Sari;Pettila, Ville;Ruokonen, Esko
通讯作者：
Ruokonen, Esko
高迁移率族蛋白1蛋白作为反映急性阑尾炎严重程度的术前诊断标志物的评价
DOI：
10.1186/1757-7241-20-61
发表时间：
2012-09-04
期刊：
Scandinavian journal of trauma, resuscitation and emergency medicine
影响因子：
--
作者：
Wu C;Sun H;Wang H;Chi J;Liu Q;Guo H;Gong J
通讯作者：
Gong J
DOI：
10.1152/ajplung.00359.2004
发表时间：
2005-05-01
影响因子：
4.9
作者：
Kim, JY;Park, JS;Abraham, E
通讯作者：
Abraham, E
影响因子：
3.7
作者：
Ramanathan, Michelle L.;MacKay, Graham;McMillan, Donald C.
通讯作者：
McMillan, Donald C.