The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma.
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma.
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细胞因子诱导的杀伤细胞治疗肺鳞状细胞癌和腺癌中基因和浸润免疫细胞的预后情况
DOI：
10.20892/j.issn.2095-3941.2021.0023
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发表时间：
2021-08-30
影响因子：
5.5
通讯作者：
Wei F
中科院分区：
文献类型：
--
作者：
Wang J;Yang F;Sun Q;Zeng Z;Liu M;Yu W;Zhang P;Yu J;Yang L;Zhang X;Ren X;Wei F
非小细胞肺癌（NSCLC）患者对尼古丁诱导的杀伤细胞（CIK）治疗的反应不同。因此，潜在的预后指标，以确定谁将受益于CIK治疗的患者必须阐明。目前的研究旨在确定有效CIK治疗NSCLC患者的预测预后标志物。组织学诊断为NSCLC的患者来自天津医科大学肿瘤研究所和医院。我们对50例NSCLC患者的肿瘤组织和配对的相邻良性组织进行了全外显子组测序（WES），并对17例NSCLC患者在CIK免疫治疗前的肿瘤组织进行了RNA-seq。多因素考克斯比例风险回归分析用于分析临床参数与预后相关性之间的关系。分析比较肺鳞癌（SCC）和腺癌（亚丁）的WES和RNA-seq数据。通过多变量考克斯比例风险回归分析（P = 0.031），肺癌的病理亚型是与DFS相关的最显着的临床参数。肺鳞癌患者CIK治疗后疗效较好，DFS延长。在肺鳞癌患者中，HLA II类基因和检查点分子的表达相对较低，免疫抑制性免疫细胞浸润较少。与肺亚丁相比，肺鳞癌中HLA II类基因和检查点分子表达的协同抑制以及较少的免疫抑制细胞浸润共同促成了更好的CIK治疗效果。
Patients with non–small cell lung cancer (NSCLC) respond differently to cytokine-induced killer cell (CIK) treatment. Therefore, potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated. The current research aimed at identifying predictive prognostic markers for efficient CIK treatment of patients with NSCLC. Patients histologically diagnosed with NSCLC were enrolled from the Tianjin Medical University Cancer Institute and Hospital. We performed whole-exome sequencing (WES) on the tumor tissues and paired adjacent benign tissues collected from 50 patients with NSCLC, and RNA-seq on tumor tissues of 17 patients with NSCLC before CIK immunotherapy treatment. Multivariate Cox proportional hazard regression analysis was used to analyze the association between clinical parameters and prognostic relevance. WES and RNA-seq data between lung squamous cell carcinoma (SCC) and adenocarcinoma (Aden) were analyzed and compared. The pathology subtype of lung cancer was the most significantly relevant clinical parameter associated with DFS, as analyzed by multivariate Cox proportional hazard regression (P = 0.031). The patients with lung SCC showed better CIK treatment efficacy and extended DFS after CIK treatment. Relatively low expression of HLA class II genes and checkpoint molecules, and less immunosuppressive immune cell infiltration were identified in the patients with lung SCC. Coordinated suppression of the expression of HLA class II genes and checkpoint molecules, as well as less immune suppressive cell infiltration together contributed to the better CIK treatment efficacy in lung SCC than lung Aden.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.1158/1078-0432.ccr-14-3039
发表时间：
2015-05-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gandara DR;Hammerman PS;Sos ML;Lara PN Jr;Hirsch FR
通讯作者：
Hirsch FR
影响因子：
7.3
作者：
Hui Z;Zhang X;Ren B;Li R;Ren X
通讯作者：
Ren X
影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
2.6
作者：
Franceschetti, Marta;Pievani, Alice;Introna, Martino
通讯作者：
Introna, Martino