A Non-Randomized Trial Investigating the Impact of Brown Rice Consumption on Gut Microbiota, Attention, and Short-Term Working Memory in Thai School-Aged Children.
A Non-Randomized Trial Investigating the Impact of Brown Rice Consumption on Gut Microbiota, Attention, and Short-Term Working Memory in Thai School-Aged Children.
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DOI：
10.3390/nu14235176
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发表时间：
2022-12-05
期刊：
影响因子：
5.9
通讯作者：
Popluechai S
中科院分区：
文献类型：
--
作者：
Gruneck L;Marriott LK;Gentekaki E;Kespechara K;Sharpton TJ;Denny J;Shannon J;Popluechai S
虽然膳食纤维已被证明会影响成人肠道微生物群的组成和认知功能，但人们对儿童纤维-微生物组-认知之间的关系知之甚少。我们对泰国北部的 127 名学龄儿童进行饮食干预之前、期间和之后，使用定量 PCR (qPCR) 分析肠道微生物群，并使用 Corsi 块敲击测试 (CBT) 和精神运动警觉测试 (PVT) 评估认知功能。虽然我们发现食用 Sinlek 大米 (SLR) 并没有显着改变肠道微生物群的丰度或学龄儿童的认知表现，但我们确实发现年龄与肠道微生物群概况和认知结果的变化有关。在两个阶段的中间时间点（第 4 周和第 61 周），对照组和 SLR 组的 γ 变形菌显着较低，并且其丰度与年龄相关。研究还发现，使用 CBT 和 PVT 的认知表现对年龄敏感，因为年龄较大的儿童在这两项认知评估中的表现均优于年龄较小的儿童。最后，多因素分析（MFA）显示，年龄和认知表现最能解释本研究中的个体差异。总的来说，这些发现进一步描述了宿主变量对泰国学龄儿童食用 Sinlek 大米的微生物特征和认知结果的影响。
While dietary fiber has been shown to influence the composition of gut microbiota and cognitive function in adults, much less is known about the fiber-microbiome-cognition association in children. We profiled gut microbiota using quantitative PCR (qPCR) and evaluated cognitive function using the Corsi block-tapping test (CBT) and the psychomotor vigilance test (PVT) before, during, and after the dietary intervention of 127 school-aged children in northern Thailand. While we found that Sinlek rice (SLR) consumption did not significantly alter the abundance of gut microbiota or the cognitive performance of school-aged children, we did find age to be associated with variations in both the gut microbiota profiles and cognitive outcomes. Gammaproteobacteria was significantly lower in the control and SLR groups during the middle time points of both phases (Weeks 4 and 61), and its abundance was associated with age. Cognitive performance using CBT and PVT were also found to be age-sensitive, as older children outperformed younger children on both of these cognitive assessments. Finally, a multiple factor analysis (MFA) revealed that age and cognitive performance best explain individual variation in this study. Collectively, these findings further describe the influence of host variables on the microbial profiles and cognitive outcomes of school-aged children consuming Sinlek rice in Thailand.
DOI：
10.1353/cpr.2012.0041
发表时间：
2012
期刊：
Progress in community health partnerships : research, education, and action
影响因子：
--
作者：
Marriott LK;Cameron WE;Purnell JQ;Cetola S;Ito MK;Williams CD;Newcomb KC;Randall JA;Messenger WB;Lipus AC;Shannon J
通讯作者：
Shannon J