Associations between alcohol consumption and hepatic steatosis in the USA.
Associations between alcohol consumption and hepatic steatosis in the USA.
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美国饮酒与肝脂肪变性之间的关系
DOI：
10.1111/liv.15020
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发表时间：
2021-09
影响因子：
6.7
通讯作者：
Jiang, Zhenghui G.
中科院分区：
文献类型：
--
作者：
Niezen, Sebasian;Trivedi, Hirsh D.;Mukamal, Kenneth J.;Jiang, Zhenghui G.
尽管被广泛认为是脂肪肝的常见原因，但酒精消费对一般人群中肝脏脂肪变性的确切影响尚不清楚。最近的国家健康和营养调查（NHANES）使我们能够研究美国成年人之间的这种关系。在此，我们从NHANES 2017-2018的4，509名参与者中提取了FibroScan的详细饮酒量和受控衰减参数（CAP）数据。与糖尿病和肥胖等代谢危险因素相比，饮酒与CAP之间的相关性不太显著。在多变量分析中，只有那些每周饮酒5-7次的人表现出CAP评分的显著增加。虽然饮酒的频率和数量与CAP评分呈正相关，但在调整数量和狂欢饮酒后，只有频率仍显着。这些流行病学观察结果表明，酒精对肝脂肪变性的影响远小于代谢因素，并取决于饮酒的频率。
Despite being widely recognized as a common cause of fatty liver, the exact impact of alcohol consumption on hepatic steatosis in the general population is elusive. The recent National Health and Nutrition Examination Survey (NHANES) allowed us to examine this relationship among US adults. Herein, we extracted data on detailed alcohol consumption and Controlled Attenuation Parameter (CAP) by FibroScan from 4,509 participants in NHANES 2017–2018. Compared to metabolic risk factors such as diabetes and obesity, the association between alcohol consumption and CAP was less significant. In multivariable analysis, only those drinking 5–7 times per week showed significant increases in CAP scores. Although both frequency and quantity of drinking were positively associated with CAP score, only frequency remained significant after adjustment for quantity and binge drinking. These epidemiological observations suggested that the impact of alcohol on hepatic steatosis was much smaller than metabolic factors and dependent upon the frequency of drinking.
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