The RNA superhighway: axonal RNA trafficking of kappa opioid receptor mRNA for neurite growth.
The RNA superhighway: axonal RNA trafficking of kappa opioid receptor mRNA for neurite growth.
复制标题
RNA 高速公路：用于轴突生长的 kappa 阿片受体 mRNA 的轴突 RNA 运输。
DOI：
10.1039/c0ib00107d
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wei,Li-Na
中科院分区：
文献类型：
--
作者：
Wei,Li-Na
神经元是高度极化的细胞，具有广泛的亚细胞区室化以适应不同的局部需求。信息在突触前（轴突）和突触后（树突）之间流动，也在索马和神经末梢之间流动。神经元通过其轴突控制有效的分子转移/运输是至关重要的。但这是非常具有挑战性的研究，因为长距离的分子必须通过轴突和轴突的各种局部环境中的明显的上下文差异，不应该孤立地检查。由于缺乏有关控制这些不同亚细胞神经元隔室之间分子流动的信息，了解阿片受体等药物反应性神经递质受体在神经元中的作用受到阻碍。最近的研究发现了新的运输系统以外的经典囊泡运输的神经元，特别是那些利用各种颗粒含有某些RNA，包括蛋白质编码的mRNA。通过利用各种实验系统、工具和方法的综合方法，研究为特定RNA颗粒在对神经元的存活和功能至关重要的几个生物过程中的功能作用提供了坚实的证据。这些包括神经元的分子/信息运输、应激反应和局部轴突翻译。通过使用κ阿片受体（KOR）作为模型，研究还揭示了KOR在发育的关键时期介导生长因子刺激的神经突生长的新生理功能，这需要特定的KOR mRNA非翻译序列来指导KOR的空间和时间特异性表达。
Neurons are highly polarized cells with extensive sub-cellular compartmentalization to accommodate diverse local needs. Information flows between the pre-synaptic (axon) and post-synaptic (dendrite) compartments, as well as between the soma and the nerve termini. It is critical that a neuron controls efficient molecular transfer/transport through its axon. But this is extremely challenging to study because of the long distance molecules must travel through axons and the apparent contextual difference in the axons' various local environments, which should not be examined in isolation. Understanding the action in neurons of drug-responsive neurotransmitter receptors such as opioid receptors has been hindered by the lack of information on the control of molecular flow between such various sub-cellular neuron compartments. Recent studies have uncovered new transport systems other than the classical vesicle transport in neurons, particularly those utilizing various granules containing certain RNAs including protein-coding mRNAs. Through integrated approaches exploiting various experimental systems, tools, and methodologies, studies have provided solid evidence for functional roles of specific RNA granules in several biological processes crucial for the survival and function of neurons. These include neurons' transport of molecules/information, stress response, and local axonal translation. By using the kappa opioid receptor (KOR) as a model, studies have also revealed a novel physiological function of KOR in mediating growth factor-stimulated neurite outgrowth during a critical period of development, which requires specific KOR mRNA untranslated sequences that direct spatially and temporally specific expression of KOR.
影响因子：
13.9
作者：
Barnes AP;Polleux F
通讯作者：
Polleux F