Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.
Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.
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DOI：
10.1371/journal.pone.0090916
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Peters WH
中科院分区：
文献类型：
--
作者：
Ong J;Salomon J;te Morsche RH;Roelofs HM;Witteman BJ;Dura P;Lacko M;Peters WH
许多因素会影响胃肠道 (GI) 癌症的发生。胰岛素样生长因子（IGF）轴在胚胎和出生后生长以及组织修复中发挥作用。 IGF 水平升高、IGF 结合蛋白 (IGFBP) 水平降低以及 IGF 受体 (IGFR-I) 过度表达与癌症的多个阶段相关。在此，研究了胃肠道癌症患者和对照者中 IGF 型 (IGF-I) 基因中的单核苷酸多态性 (SNP) rs6214 和生长激素受体 (GHR) 基因中的 rs6898743 的患病率。在这项荷兰病例对照研究中，从 1,457 名胃肠道癌症患者的血液中分离出 DNA； 438 名头颈癌 (HNC) 患者、475 名食道癌 (EC) 患者和 544 名结直肠癌 (CRC) 患者以及 1,457 名匹配对照者通过聚合酶链反应测定了 rs6214 和 rs6898743 基因型。研究了这些 SNP 与胃肠道癌、HNC、食管腺癌 (EAC)、食管鳞状细胞癌 (ESCC) 和近端或远端 CRC 之间的关联。通过无条件逻辑回归计算具有 95% 置信区间 (95% CI) 的优势比 (OR)。总体而言，对于胃肠道癌症，使用最常见的基因型 GG 作为参考，SNP rs6214 和 rs6898743 的 OR 约为 1.0（p 值>0.05）。 rs6214 基因型 AA 的 EC 的 OR 为 1.54（95% CI，1.05-2.27）。对于基因型 GA 和 AA，EAC 的 OR 分别为 1.45 (95% CI，1.04–2.01) 和 1.71 (95% CI，1.10–2.68)。 rs6898743 的基因型 GC 显示 ESCC 的 OR 为 0.47 (95% CI, 0.26–0.86)。 IGF-I 基因中的 SNP rs6214 的 A 等位基因与 EAC 以及女性的 HNC 相关。 GHR基因中rs6898743的GC基因型与ESCC呈负相关。
Numerous factors influence the development of gastrointestinal (GI) cancer. The insulin-like growth factor (IGF) axis plays a role in embryonic and postnatal growth and tissue repair. Elevated levels of IGFs, low levels of IGF binding proteins (IGFBPs) and over-expression of IGF receptor (IGFR-I) were associated with several stages of cancer. Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. In this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction. The association between these SNPs and GI cancer, HNC, esophageal adenocarcinoma (EAC), esophageal squamous-cell carcinoma (ESCC) and proximal or distal CRC was studied. Odds ratios (ORs) with 95% confidence interval (95% CI) were calculated via unconditional logistic regression. Overall for GI cancer, the ORs for SNPs rs6214 and rs6898743 were approximately 1.0 (p-value>0.05), using the most common genotypes GG as reference. An OR of 1.54 (95% CI, 1.05–2.27) was found for EC for genotype AA of rs6214. The ORs for EAC were 1.45 (95% CI, 1.04–2.01) and 1.71 (95% CI, 1.10–2.68), for genotypes GA and AA, respectively. Genotype GC of rs6898743 showed an OR of 0.47 (95% CI, 0.26–0.86) for ESCC. The A allele of SNP rs6214 in the IGF-I gene was associated with EAC, and with HNC in women. The GC genotype of rs6898743 in the GHR gene was negatively associated with ESCC.
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影响因子：
8.8
作者：
通讯作者：
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影响因子：
2.7
作者：
Kim, Hak Jae;Kim, Su Kang;Kim, Young Ock
通讯作者：
Kim, Young Ock
DOI：
10.1158/1055-9965.epi-08-0856
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
D'Aloisio AA;Schroeder JC;North KE;Poole C;West SL;Travlos GS;Baird DD
通讯作者：
Baird DD
影响因子：
8.8
作者：
Macaulay, V M
通讯作者：
Macaulay, V M
影响因子：
1.4
作者：
Ma, J;Pollak, M;Stampfer, MJ
通讯作者：
Stampfer, MJ