Use of host lipids by the Lyme disease spirochete may lead to biomarkers.
Use of host lipids by the Lyme disease spirochete may lead to biomarkers.
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DOI：
10.1172/jci158254
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Fikrig E
中科院分区：
文献类型：
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作者：
Arora G;Hart T;Fikrig E
莱姆病是北美和欧洲最常见的蜱传疾病，然而，目前的生物标志物并不能一致地检测到这种疾病。在这一期的JCI中，Gwynne等人揭示了莱姆病病原体伯氏疏螺旋体如何依赖宿主脂质生长。作者使用小鼠模型来证明B。伯氏螺旋体感染导致抗磷脂抗体的产生，这可能是掺入螺旋体膜的结果。诱导抗体对磷脂酸，磷脂酰胆碱，磷脂酰丝氨酸。值得注意的是，没有发现针对心磷脂的抗体，从而将莱姆病与梅毒和其他一些疾病区分开来。莱姆病患者的血清样本表明，这些抗体可能有助于诊断B。因此，本发明人认识到，抗体滴度可以有效地指示对治疗的反应。这些结果表明，B。检测莱姆病引起的抗脂质抗体，结合仔细的临床评估，可能有助于莱姆病的诊断。
Lyme disease is the most common tick-borne disease in North America and Europe, however, current biomarkers inconsistently detect the disease. In this issue of the JCI, Gwynne et al. revealed how the Lyme disease agent Borrelia burgdorferi relies on host lipids for growth. The authors used a murine model to show that B. burgdorferi infection led to the production of antibodies against phospholipids, possibly as a consequence of incorporation into the spirochete membrane. Antibodies were induced against phosphatidic acid, phosphatidylcholine, and phosphatidylserine. Notably, no antibodies against cardiolipin were found, distinguishing Lyme disease from syphilis and some other diseases. Sera samples from patients with Lyme disease suggested that these antibodies may help diagnose B. burgdorferi infection and that antibody titers may effectively indicate the response to treatment. These findings suggest that B. burgdorferi–induced anti-lipid antibodies, in conjunction with a careful clinical assessment, may aid in the diagnosis of Lyme disease.
伯氏疏螺旋体的基因组缩减：两种不同宿主栖息地的两种 TCS 信号通路
DOI：
10.1007/s11427-015-4996-z
发表时间：
2016-01
期刊：
Science China. Life sciences
影响因子：
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作者：
Ye M;Zhou Y;Lou Y;Yang XF
通讯作者：
Yang XF