Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.
Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.
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DOI：
10.1371/journal.pone.0045461
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Zou L;Zhong R;Lou J;Lu X;Wang Q;Yang Y;Xia J;Ke J;Zhang T;Sun Y;Liu L;Cui Y;Xiao H;Chang L;Xia D;Xu H
一个常见的单核苷酸多态性（SNP），rs3802842，位于11 q23，被全基因组关联研究（GWAS）确定为与结直肠癌（CRC）的风险显着相关;然而，以下复制研究的结果并不总是一致的。因此，进行了病例对照研究和荟萃分析，以清楚地辨别这种变异在CRC中的作用。我们确定了641例无亲缘关系的中国结直肠癌患者和1037例无癌对照的rs3802842基因型。此外，还进行了一项荟萃分析，包括当前和先前发表的研究。在我们的病例对照研究中，在所有遗传模型中观察到多态性与CRC风险之间的显著关联，加性OR为1.45（95%CI = 1.26-1.67）。 对38534例病例和39446例对照的荟萃分析进一步证实了所有遗传模型中的显著关联，但具有明显的研究间异质性。然而，种族、研究类型和受试者是否患有Lynch综合征可以综合解释异质性。此外，累积和敏感性分析表明，结果的稳健稳定性。我们的病例对照研究和荟萃分析的结果提供了令人信服的证据，证明rs3802842显著增加了CRC风险。
A common single nucleotide polymorphism (SNP), rs3802842, located at 11q23, was identified by genome-wide association studies (GWAS) to be significantly associated with the risk of colorectal cancer (CRC); however, the results of following replication studies were not always concordant. Thus, a case-control study and a meta-analysis were performed to clearly discern the effect of this variant in CRC. We determined the genotypes of rs3802842 in 641 unrelated Chinese patients with CRC and 1037 cancer-free controls. Additionally, a meta-analysis comprising current and previously published studies was conducted. In our case-control study, significant associations between the polymorphism and CRC risk were observed in all genetic models, with an additive OR being 1.45 (95% CI = 1.26–1.67). The meta-analysis of 38534 cases and 39446 controls further confirmed the significant associations in all genetic models but with obvious between-study heterogeneity. Nevertheless, ethnicity, study type and whether subjects affected by Lynch syndrome could synthetically accounted for the heterogeneity. Besides, the cumulative and sensitivity analyses indicated the robust stability of the results. The results from our case-control study and meta-analysis provided convincing evidence that rs3802842 significantly contributed to CRC risk.
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影响因子：
5.1
作者：
Chen, Wan-qing;Zeng, Hong-mei;He, Jie
通讯作者：
He, Jie
影响因子：
11.2
作者：
Hutter, Carolyn M.;Chang-Claude, Jenny;Peters, Ulrike
通讯作者：
Peters, Ulrike
影响因子：
--
作者：
Niittymäki I;Tuupanen S;Li Y;Järvinen H;Mecklin JP;Tomlinson IP;Houlston RS;Karhu A;Aaltonen LA
通讯作者：
Aaltonen LA
影响因子：
4
作者：
Talseth-Palmer, Bente A.;Brenne, Ingvild S.;Scott, Rodney J.
通讯作者：
Scott, Rodney J.
影响因子：
29.4
作者：
Kupfer SS;Anderson JR;Hooker S;Skol A;Kittles RA;Keku TO;Sandler RS;Ellis NA
通讯作者：
Ellis NA