Adult zebrafish as advanced models of human disease.

Adult zebrafish as advanced models of human disease.
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DOI:
10.1242/dmm.050351
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发表时间:
2023-08-01
影响因子:
4.3
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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模拟成人疾病以了解其病因和进展,并开发新的治疗方法,是医学生物学的一个重大挑战。我们对斑马鱼社区开发成人疾病模型的新努力感到兴奋,这些疾病包括癌症、心脏病、传染病和年龄相关疾病,以及与毒理学和复杂社会行为有关的疾病。在这里,我们讨论了一些在成年疾病的斑马鱼模型领域的进展,以及我们看到的机遇和挑战。总结:斑马鱼胚胎和幼体极大地促进了我们对人类发育和疾病的理解,但最近的进展现在使成年斑马鱼的使用具有独特的优势,用于模拟成年疾病。
Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. Here, we discuss some of the advances in the field of zebrafish models of adult disease, and where we see opportunities and challenges ahead. Summary: Zebrafish embryos and larvae have greatly contributed to our understanding of human development and disease, but recent advances are now enabling the use of adult zebrafish that have unique advantages for modelling adult disease.
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