Ventilatory expired gas at constant-rate low-intensity exercise predicts adverse events and is related to neurohormonal markers in patients with heart failure.
Ventilatory expired gas at constant-rate low-intensity exercise predicts adverse events and is related to neurohormonal markers in patients with heart failure.
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DOI：
10.1016/j.cardfail.2008.12.015
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发表时间：
2009-08
影响因子：
6
通讯作者：
Johnson B
中科院分区：
文献类型：
--
作者：
Arena R;MacCarter D;Olson TP;Lalande S;Ceridon ML;Olson LJ;Johnson B
呼吸效率(VE/VCO2比率)和呼气末二氧化碳分压(PETCO2)，在中到高水平的体力消耗时获得，对心力衰竭(HF)有预测价值。本研究评估了这些变量在低强度运动中的临床应用。130名被诊断为心衰的受试者以每小时2英里的速度进行了2分钟的恒速跑步机训练。记录运动时的VE/VCO2比值和PETCO2(平均30秒)及其与安静时的变化(Δ)。同时测定B型和心钠素(BNP、ANP)。多因素COX回归分析仅有PETCO2和ΔPETCO2进入回归方程。受试者操作特征曲线分析显示预后分级方案有显著意义，以<lt；/≥34 mm Hg(危险比：4.2，95%CI：2.2~8.0，P<；.001)和<；/≥1 mm Hg(危险比：3.5，95%CI：1.9~6.6，P<；.001)分别为PETCO2和ΔPETCO2的最佳阈值。此外，PETCO2≥为34 mm Hg的受试者的BNP(214.1±431.9比1110.5±1854.0 pg/mL，P=0.005)和ANP(108.2±103.6比246.2±200.4 pg/mL，P<；.001)显著降低。这项初步研究的结果表明，在短时间的低强度运动中，呼吸机呼出气体的分析可以提供对预后和心脏稳定性的洞察。
Ventilatory efficiency (VE/VCO2 ratio) and the partial pressure of end-tidal carbon dioxide (PETCO2), obtained during moderate to high levels of physical exertion demonstrate prognostic value in heart failure (HF). The present investigation assesses the clinical utility of these variables during low-intensity exercise. One hundred and thirty subjects diagnosed with HF underwent a 2-minute, constant-rate treadmill session at 2 miles per hour. Both the VE/VCO2 ratio and PETCO2 were recorded during exercise (30-second average) and their change (Δ) from rest. B-type and atrial natriuretic peptide (BNP and ANP) were also determined. Only PETCO2 and ΔPETCO2 emerged from the multivariate Cox regression. Receiver operating characteristic curve analysis revealed the prognostic classification schemes were significant with thresholds of </≥34 mm Hg (hazard ratio: 4.2, 95% CI: 2.2–8.0, P < .001) and </≥1 mm Hg (hazard ratio: 3.5, 95% CI: 1.9–6.6, P < .001) being optimal for PETCO2 and Δ PETCO2, respectively. Moreover, subjects with a PETCO2≥34 mm Hg had a significantly lower BNP (214.1 ± 431.9 vs. 1110.5 ± 1854.0 pg/mL, P =.005) and ANP (108.2 ± 103.6 vs. 246.2 ± 200.4 pg/mL, P < .001). The results of this pilot study indicate ventilatory expired gas analysis during a short bout of low-intensity exercise may provide insight into prognosis and cardiac stability.
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影响因子：
37.8
作者：
Arena, Ross;Myers, Jonathan;Guazzi, Marco
通讯作者：
Guazzi, Marco
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1016/s0735-1097(02)02164-2
发表时间：
2002-10-16
影响因子：
24
作者：
Gibbons, RJ;Balady, GJ;Smith, SC
通讯作者：
Smith, SC
影响因子：
9.6
作者：
Koike, A;Itoh, H;Watanabe, H
通讯作者：
Watanabe, H
影响因子：
56.9
作者：
BURNETT, JC;KAO, PC;REEDER, GS
通讯作者：
REEDER, GS