Periodontal Disease: The Good, The Bad, and The Unknown.
Periodontal Disease: The Good, The Bad, and The Unknown.
复制标题
DOI：
10.3389/fcimb.2021.766944
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Kapila YL
中科院分区：
文献类型：
--
作者：
Sedghi LM;Bacino M;Kapila YL
牙周病的典型特征是牙周复合体软硬组织的渐进式破坏，这是由牙龈和牙周组织内的益生菌群落和异常免疫反应之间的相互作用介导的。假定的牙周病原体会随着口腔微生物群的失调和炎症反应引起组织破坏而富集，从而诱导牙周病原体的蛋白水解、炎症和富集的不懈正反馈循环。关键微生物病原体和持续的牙龈炎症是牙周病进展的关键。然而，最近的研究揭示了以前未知的微生物在疾病进展中的重要性，包括各种病毒、噬菌体和细菌物种。此外，近年来新发现的免疫和遗传机制以及环境宿主因素，包括饮食和生活方式，已被认为是牙周炎的进一步促进因素。这些因素共同扩大了牙周病进展的既定叙述。与此相一致的是，与维持牙周健康和治疗现有疾病有关的新思想已经被探索，例如口服益生菌的应用，以限制和减轻疾病的进展。全身宿主病理，如自身免疫性疾病和糖尿病，在牙周病发病机制中的作用已得到很好的注意。最近的研究还发现，牙周病在远端部位增强全身性疾病状态（如阿尔茨海默病、炎症性肠病和口腔癌）方面的相互重要性，进一步强调了口腔在全身性健康中的重要性。在这里，我们回顾了牙周病进展的长期知识，同时整合了新的研究概念，拓宽了我们对牙周健康和疾病的理解。此外，我们深入到创新的假设，可能演变，以解决重大差距在牙周病的基础知识。
Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the periodontal complex, mediated by an interplay between dysbiotic microbial communities and aberrant immune responses within gingival and periodontal tissues. Putative periodontal pathogens are enriched as the resident oral microbiota becomes dysbiotic and inflammatory responses evoke tissue destruction, thus inducing an unremitting positive feedback loop of proteolysis, inflammation, and enrichment for periodontal pathogens. Keystone microbial pathogens and sustained gingival inflammation are critical to periodontal disease progression. However, recent studies have revealed the importance of previously unidentified microbes involved in disease progression, including various viruses, phages and bacterial species. Moreover, newly identified immunological and genetic mechanisms, as well as environmental host factors, including diet and lifestyle, have been discerned in recent years as further contributory factors in periodontitis. These factors have collectively expanded the established narrative of periodontal disease progression. In line with this, new ideologies related to maintaining periodontal health and treating existing disease have been explored, such as the application of oral probiotics, to limit and attenuate disease progression. The role of systemic host pathologies, such as autoimmune disorders and diabetes, in periodontal disease pathogenesis has been well noted. Recent studies have additionally identified the reciprocated importance of periodontal disease in potentiating systemic disease states at distal sites, such as in Alzheimer’s disease, inflammatory bowel diseases, and oral cancer, further highlighting the importance of the oral cavity in systemic health. Here we review long-standing knowledge of periodontal disease progression while integrating novel research concepts that have broadened our understanding of periodontal health and disease. Further, we delve into innovative hypotheses that may evolve to address significant gaps in the foundational knowledge of periodontal disease.
登录
查看更多内容
抗生素在牙周治疗中的辅助使用。
影响因子：
--
作者：
Barca E;Cifcibasi E;Cintan S
通讯作者：
Cintan S
牙周疾病和衰老细胞：旧口腔健康问题的新参与者？
影响因子：
5.6
作者：
Aquino-Martinez R;Khosla S;Farr JN;Monroe DG
通讯作者：
Monroe DG
影响因子：
4
作者：
Beydoun, May A.;Beydoun, Hind A.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
11
作者：
Abeles, Shira R.;Robles-Sikisaka, Refugio;Pride, David T.
通讯作者：
Pride, David T.
影响因子：
3.4
作者：
Ateia IM;Sutthiboonyapan P;Kamarajan P;Jin T;Godovikova V;Kapila YL;Fenno JC
通讯作者：
Fenno JC