Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
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DOI：
10.3389/fimmu.2018.02492
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发表时间：
2018
影响因子：
7.3
通讯作者：
Fallon PG
中科院分区：
文献类型：
--
作者：
Schwartz C;Fallon PG
血吸虫病是由血吸虫属寄生吸虫的慢性感染引起的人类发病的主要原因。血吸虫有一个复杂的生命周期，包括感染水生蜗牛中间宿主和最终哺乳动物宿主。在人类中，成年雄性和雌性蠕虫位于脉管系统内。在这里，它们繁殖并产卵。然后这些卵必须从宿主体内释放出来以继续生命周期。曼氏血吸虫和日本血吸虫寄生在肠的肠系膜循环中，虫卵通过粪便排出。相反，S.在膀胱的静脉丛中有一种产血吸虫，在尿液中排出虫卵。在一个令人印象深刻的利用宿主免疫系统的案例中，血吸虫“产卵”宿主的过程是免疫依赖的。本文就虫卵肉芽肿的形成及S.在脉管系统中产下的曼氏菌卵必须篡夺免疫力以诱导受调节的炎症、促进通过肠壁的外渗并在粪便中排出。我们强调了免疫细胞群，基质因子和卵子分泌物在卵子排泄过程中的作用，以全面概述目前关于一个尚未探索的机制的知识。
Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail intermediate host and a definitive mammalian host. In humans, adult male and female worms lie within the vasculature. Here, they propagate and eggs are laid. These eggs must then be released from the host to continue the life cycle. Schistosoma mansoni and Schistosoma japonicum reside in the mesenteric circulation of the intestines with egg excreted in the feces. In contrast, S. haematobium are present in the venus plexus of the bladder, expelling eggs in the urine. In an impressive case of exploitation of the host immune system, this process of Schistosome “eggs-iting” the host is immune dependent. In this article, we review the formation of the egg granuloma and explore how S. mansoni eggs laid in vasculature must usurp immunity to induce regulated inflammation, to facilitate extravasation through the intestinal wall and to be expelled in the feces. We highlight the roles of immune cell populations, stromal factors, and egg secretions in the process of egg excretion to provide a comprehensive overview of the current state of knowledge regarding a vastly unexplored mechanism.
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影响因子：
6.4
作者：
Boros, DL;Whitfield, JR
通讯作者：
Whitfield, JR
影响因子：
8.1
作者：
Colley DG;Andros TS;Campbell CH Jr
通讯作者：
Campbell CH Jr
DOI：
10.4269/ajtmh.1993.48.496
发表时间：
1993-04-01
影响因子：
3.3
作者：
CHEEVER, AW;ELTOUM, IA;COX, TM
通讯作者：
COX, TM
影响因子：
64.8
作者：
AMIRI, P;LOCKSLEY, RM;MCKERROW, JH
通讯作者：
MCKERROW, JH
影响因子：
2.9
作者：
Bautista-Garfias, CR;Ixta-Rodríguez, O;Aguilar-Figueroa, BR
通讯作者：
Aguilar-Figueroa, BR