Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide.
Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide.
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尿胰蛋白酶抑制剂对脂多糖诱导的全身性炎症反应的保护作用。
DOI：
10.3164/jcbn.2008059
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发表时间：
2008-11
影响因子：
2.4
通讯作者：
Yoshikawa, Toshikazu
中科院分区：
文献类型：
--
作者：
Inoue, Ken-ichiro;Takano, Hirohisa;Yanagisawa, Rie;Yoshikawa, Toshikazu
尿胰蛋白酶抑制剂（UTI）是一种丝氨酸蛋白酶抑制剂，在日本已被广泛用作急性炎症性疾病（如弥散性血管内凝血（DIC）、休克和胰腺炎）患者的药物。最近的体外研究表明，丝氨酸蛋白酶抑制剂可能具有抗炎特性，而不仅仅是在炎症部位抑制中性粒细胞弹性蛋白酶。然而，UTI在体内的治疗效果仍不清楚。在这篇综述中，我们介绍了UTI在实验性全身炎症反应中的作用，所述实验性全身炎症反应由使用UTI缺陷型和野生型小鼠腹腔内和腹腔内给予脂多糖诱导。我们的实验表明，UTI可以保护全身炎症反应和随后的器官损伤引起的细菌内毒素，至少部分，通过抑制促炎细胞因子和趋化因子的表达。因此，UTI可能为全身炎症反应综合征（如DIC、急性肺损伤和多器官功能障碍）提供了一种有吸引力的“拯救”治疗选择。
Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation (DIC), shock, and pancreatitis. Recent in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil elastase at the site of inflammation. However, the therapeutic effects of UTI in vivo remain unclear. In this review, we introduce the roles of UTI in the experimental systemic inflammatory response induced by both intraperitoneal and intratracheal administration of lipopolysaccharide using UTI deficient and wild-type mice. Our experiments suggest that UTI can protect against systemic inflammatory response and subsequent organ injury induced by bacterial endotoxin, at least partly, through the inhibition of proinflammatory cytokine and chemokine expression. UTI may therefore present an attractive “rescue” therapeutic option for systemic inflammatory response syndromes such as DIC, acute lung injury, and multiple organ dysfunction.
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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作者：
Tkalcevic, J;Novelli, M;Roes, J
通讯作者：
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