The Gene Ontology resource: enriching a GOld mine.
The Gene Ontology resource: enriching a GOld mine.
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DOI：
10.1093/nar/gkaa1113
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Gene Ontology Consortium
中科院分区：
文献类型：
--
作者：
Gene Ontology Consortium
基因本体论联盟（GOC）提供了目前最全面的关于基因和基因产物功能的可计算知识资源。在此，我们报告该财团在过去两年中取得的进展。新的GO-CAM注释框架得到了显着改进，我们用计算模式对模型进行了形式化，以检查和验证快速增长的2838个GO-CAM库。此外，我们描述了几个合作的影响，以完善GO和报告的GO注释的数量增加了10%，注释的基因产品增加了25%，和超过9,400个新的科学文章注释。随着项目的成熟，我们将继续努力根据新的发现来审查旧的注释，并与其他本体保持一致。结果，20 000注释来自实验数据进行了审查，相当于2.5%的实验GO注释。重新设计了网站（http：geneontology.org），以便快速查阅文件、下载和使用工具。为了保持准确的资源并支持可追溯性和可再现性，我们提供了一个历史档案，涵盖了过去15年的GO数据，其中包括本体和注释的一致格式和文件结构。
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.
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影响因子：
14.9
作者：
Lombardot T;Morgat A;Axelsen KB;Aimo L;Hyka-Nouspikel N;Niknejad A;Ignatchenko A;Xenarios I;Coudert E;Redaschi N;Bridge A
通讯作者：
Bridge A
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
3
作者：
Deegan (nee Clark), Jennifer I.;Dimmer, Emily C.;Mungall, Christopher J.
通讯作者：
Mungall, Christopher J.
影响因子：
1.3
作者：
Dillen, Mathias;Groom, Quentin;Phillips, Sarah
通讯作者：
Phillips, Sarah
影响因子：
5.8
作者：
Wood V;Carbon S;Harris MA;Lock A;Engel SR;Hill DP;Van Auken K;Attrill H;Feuermann M;Gaudet P;Lovering RC;Poux S;Rutherford KM;Mungall CJ
通讯作者：
Mungall CJ