The NIH-NIAID schistosomiasis resource center.
The NIH-NIAID schistosomiasis resource center.
复制标题
NIH-NIAID螺旋菌病资源中心。
DOI：
10.1371/journal.pntd.0000267
复制
发表时间：
2008-07-30
影响因子：
3.8
通讯作者：
Knight, Matty
中科院分区：
文献类型：
--
作者：
Lewis, Fred A.;Liang, Yung-san;Raghavan, Nithya;Knight, Matty
研究血吸虫病的科学家必须做出很大的承诺，以维持寄生虫的生命周期，这必然涉及哺乳动物（最终）宿主和适当种类的蜗牛（中间宿主）。这往往是一个困难和昂贵的承诺，特别是在面对热带疾病研究资金日益紧缩的情况下。除了资金问题，调查人员通常面临额外的问题，在分配足够的实验室空间，这项工作（特别是蜗牛饲养）和有限的可用性与生命周期的维护经验的人员。这些问题对于新进入该领域的调查员来说尤其令人生畏。40多年前，美国国立卫生研究院-国家过敏和传染病研究所（NIH-NIAID）有远见地建立了一个资源，研究人员可以从中获得各种令人烦恼的生命阶段，而不必花费必要的精力和资金来维持整个生命周期。这种集中的资源转化为成本节约NIH-NIAID和主要研究人员通过释放赠款的人员成本，并允许研究人员将更多的资金转移到有针对性的研究目标。许多研究人员，特别是那些新的热带医学领域，只有模糊的，如果在所有，知道的范围内的材料和支持提供的这一资源。这次审查旨在帮助纠正这种情况。在简短的合同历史之后，我们将简要描述所提供的令人讨厌的物种，估计资源对研究界的影响，并描述资源中心可能为不断变化的研究人员的研究兴趣带来的一些新的补充和潜在利益。
A bench scientist studying schistosomiasis must make a large commitment to maintain the parasite's life cycle, which necessarily involves a mammalian (definitive) host and the appropriate species of snail (intermediate host). This is often a difficult and expensive commitment to make, especially in the face of ever-tightening funds for tropical disease research. In addition to funding concerns, investigators usually face additional problems in the allocation of sufficient lab space to this effort (especially for snail rearing) and the limited availability of personnel experienced with life cycle upkeep. These problems can be especially daunting for the new investigator entering the field. Over 40 years ago, the National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) had the foresight to establish a resource from which investigators could obtain various schistosome life stages without having to expend the effort and funds necessary to maintain the entire life cycle on their own. This centralized resource translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are only vaguely, if at all, aware of the scope of materials and support provided by this resource. This review is intended to help remedy that situation. Following a short history of the contract, we will give a brief description of the schistosome species provided, provide an estimate of the impact the resource has had on the research community, and describe some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators.
登录
查看更多内容
影响因子：
1.3
作者：
COOPER, LA;LEWIS, FA;FILEEMPERADOR, S
通讯作者：
FILEEMPERADOR, S
影响因子：
8.8
作者：
FRIPP, PJ
通讯作者：
FRIPP, PJ
DOI：
10.4269/ajtmh.2000.63.133
发表时间：
2000-09-01
影响因子：
3.3
作者：
Hodder, SL;Mahmoud, AAF;King, CH
通讯作者：
King, CH
DOI：
10.4269/ajtmh.1984.33.116
发表时间：
1984-01-01
影响因子：
3.3
作者：
STIREWALT, M;LEWIS, FA;LEEF, JL
通讯作者：
LEEF, JL
DOI：
10.1016/0035-9203(77)90143-2
发表时间：
1977-01-01
影响因子：
2.2
作者：
JAMES, ER;FARRANT, J
通讯作者：
FARRANT, J