A novel nairovirus associated with acute febrile illness in Hokkaido, Japan.
A novel nairovirus associated with acute febrile illness in Hokkaido, Japan.
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DOI：
10.1038/s41467-021-25857-0
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发表时间：
2021-09-20
影响因子：
16.6
通讯作者：
Matsuno K
中科院分区：
文献类型：
--
作者：
Kodama F;Yamaguchi H;Park E;Tatemoto K;Sashika M;Nakao R;Terauchi Y;Mizuma K;Orba Y;Kariwa H;Hagiwara K;Okazaki K;Goto A;Komagome R;Miyoshi M;Ito T;Yamano K;Yoshii K;Funaki C;Ishizuka M;Shigeno A;Itakura Y;Bell-Sakyi L;Edagawa S;Nagasaka A;Sakoda Y;Sawa H;Maeda K;Saijo M;Matsuno K
诸如克里米亚-刚果出血热等扁虱传播的正畸病毒感染的负担日益加重，正在成为公共卫生的全球关注问题。在本研究中，我们分别于2019年和2020年从日本北海道的两名急性发热患者中分离到一种新的正畸病毒，命名为Yezo病毒(YEZV)，患者表现为血小板减少症和扁虱叮咬后白细胞减少症。YEZV在系统发育上与在罗马尼亚蓖麻硬蜱中检测到的苏林纳病毒属一类。2014-2020年，已确诊7名患者感染YEZV，其中4人合并感染疏螺旋体。在野鹿和浣熊中发现了YEZV抗体，在北海道的扁虱中也检测到了YEZV RNA。在这项工作中，我们证明YEZV极有可能是发热性疾病的病原体，这是日本首次报告与一种可能由壁虱传播的正畸病毒有关的地方性感染。在这里，KoDama等人。描述从日本一种急性发热性疾病的患者中发现、分离和鉴定一种新的壁虱传播的正畸病毒，命名为Yezo病毒(YEZV)。对野生动物的血清学检测和对扁虱的分子筛查表明，日本存在YEZV的地方性传播。
The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan. Here, Kodama et al. describe the discovery, isolation and characterization of a novel tick-borne orthonairovirus, designated Yezo virus (YEZV), from patients with an acute febrile illness in Japan. Serological testing of wildlife and molecular screening of ticks suggest an endemic circulation of YEZV in Japan.
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影响因子：
3.9
作者：
Seki M;Watanabe Y;Kawabata H
通讯作者：
Kawabata H
DOI：
10.1292/jvms.15-0536
发表时间：
2016-03
期刊：
The Journal of veterinary medical science
影响因子：
--
作者：
Oba M;Omatsu T;Takano A;Fujita H;Sato K;Nakamoto A;Takahashi M;Takada N;Kawabata H;Ando S;Mizutani T
通讯作者：
Mizutani T
影响因子：
3.7
作者：
Takano A;Toyomane K;Konnai S;Ohashi K;Nakao M;Ito T;Andoh M;Maeda K;Watarai M;Sato K;Kawabata H
通讯作者：
Kawabata H
影响因子：
11.8
作者：
Sato K;Takano A;Konnai S;Nakao M;Ito T;Koyama K;Kaneko M;Ohnishi M;Kawabata H
通讯作者：
Kawabata H
影响因子：
3.1
作者：
Li, Z;Yu, M;Wang, LF
通讯作者：
Wang, LF