Ejection characteristics in primary pulmonary hypertension.
Ejection characteristics in primary pulmonary hypertension.
复制标题
原发性肺动脉高压的射血特征。
DOI：
10.1016/0002-9149(93)90584-y
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
William G. Kussmaul
中科院分区：
文献类型：
--
作者：
Warren K. Laskey;Warren K. Laskey;Victor A. Ferrari;Victor A. Ferrari;H. I. Palevsky;H. I. Palevsky;William G. Kussmaul;William G. Kussmaul
原发性肺动脉高压（PPH）是一种进行性肺循环血管病变，导致肺动脉（PA）压力和肺血管阻力显著升高。1 - 3最初在静息状态下保持的心输出量不会随着运动而适当增加。2，4，5这些特征的组合解释了这些患者经常出现的疲劳和呼吸困难的临床症状。虽然有大量的数据表明PPH患者的中心血流动力学特征，但这些研究大多集中在非搏动性测量上。射血的阶段性或动态性质的表征不仅提供了瞬时射血性能的详细测量，而且可以提供对发病机制的重要见解。6外部血管负荷的改变将可预测地影响心室射血性能。本研究比较了PPH患者与年龄匹配的对照人群在静息和运动时的右侧动态射血行为。我们的目的是证明肺循环中的相位血流动力学反映PA血管水力负荷的大小和性质。
Primary pulmonary hypertension (PPH) is a progressive vasculopathy of the pulmonary circulation which results in marked elevations of pulmonary artery (PA) pressure and pulmonary vascular resistance.1–3Cardiac output, initially preserved at rest, does not increase appropriately with exercise.2,4,5This combination of features explains the clinical symptoms of fatigue and dyspnea frequently present in these patients. Although considerable data exist characterizing central hemodynamics in patients with PPH, most of these studies have focused on nonpulsatile measures. Characterization of the phasic, or dynamic, nature of ejection not only provides detailed measures of instantaneous ejection performance but also can provide important insight into pathogenetic mechanisms.6Alterations in external vascular load will predictably affect ventricular ejection performance. The present study compares and contrasts right-sided dynamic ejection behavior at rest and during exercise in patients with PPH with an age-matched control population. Our intent was to demonstrate that phasic hemodynamics in the pulmonary circulation reflect the magnitude and nature of the PA vascular hydraulic load.
DOI：
10.1164/arrd.1984.129.2p2.s93
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Janicki,JS;Weber,KT;Likoff,MJ;Fishman,AP
通讯作者：
Fishman,AP