Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.
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DOI：
10.1021/np800751j
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发表时间：
2009-05-22
影响因子：
5.1
通讯作者：
Orjala, Jimmy
中科院分区：
文献类型：
--
作者：
Mo, Shunyan;Krunic, Aleksej;Chlipala, George;Orjala, Jimmy
通过生物测定引导的分级分离，从培养的蓝细菌 Fischerella ambigua (UTEX 1903) 中分离出五种新的抗菌模糊 K-O 异腈 (1-5) 和九种先前描述的吲哚生物碱。新化合物的平面结构通过光谱分析（包括 MS、1D- 和 2D-NMR）确定。 X 射线晶体学用于确定模糊 K 异腈的绝对立体构型。评估了这些分离株对一系列细菌靶标（包括结核分枝杆菌和炭疽杆菌）的抗菌活性。模糊 K 和 M 异腈对结核分枝杆菌表现出最有效的活性，MIC 值分别为 6.6 μM 和 7.5 μM。 Ambiguine A 异腈对炭疽芽孢杆菌表现出最有效的活性，MIC 为 1.0 μM。
Five new antibacterial ambiguine K-O isonitriles (1-5) and nine previously described indole alkaloids were isolated from the cultured cyanobacterium Fischerella ambigua (UTEX 1903) by bioassay-guided fractionation. The planar structures of the new compounds were determined by spectroscopic analysis including MS, 1D- and 2D-NMR. X-ray crystallography was used to determine the absolute stereo-configuration of ambiguine K isonitrile. The isolates were evaluated for their antibacterial activities against a set of bacterial targets, including Mycobacterium tuberculosis and Bacillus anthracis. Ambiguine K and M isonitriles showed the most potent activity against M. tuberculosis with MIC values of 6.6 μM and 7.5 μM, respectively. Ambiguine A isonitrile showed the most potent activity against B. anthracis with a MIC of 1.0 μM.
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