Glucocorticoids and endothelial cell barrier function.
Glucocorticoids and endothelial cell barrier function.
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DOI：
10.1007/s00441-013-1762-z
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发表时间：
2014-03
影响因子：
3.6
通讯作者：
Foerster, Carola
中科院分区：
文献类型：
--
作者：
Salvador, Ellaine;Shityakov, Sergey;Foerster, Carola
糖皮质激素（GC）是类固醇激素，对多种细胞具有炎症和免疫抑制作用。它们被用作炎性疾病的治疗和作为抗水肿的常用药物。血脑屏障（BBB）包括微血管内皮细胞，用作血液和脑之间的渗透屏障。因此，它维持中枢神经系统（CNS）的稳态。在许多CNS疾病中，BBB完整性受损。GC治疗已被证明可以改善BBB的紧密性。GC的反应和作用由普遍存在的GC受体（GR）介导。配体结合的GR识别并结合位于靶基因启动子区域内的GC反应元件。某些靶基因的反式激活导致内皮细胞的屏障性质改善。在这篇综述中，我们处理的GC在内皮细胞屏障功能的作用。首先，我们在分子水平上描述GC作用的机制。接下来，我们讨论了GCs对BBB的调节，重点是GCs靶向的基因，如occludin，claudins和VE-钙粘蛋白。最后，我们提出了目前可用的GC治疗策略及其局限性。
Glucocorticoids (GCs) are steroid hormones that have inflammatory and immunosuppressive effects on a wide variety of cells. They are used as therapy for inflammatory disease and as a common agent against edema. The blood brain barrier (BBB), comprising microvascular endothelial cells, serves as a permeability screen between the blood and the brain. As such, it maintains homeostasis of the central nervous system (CNS). In many CNS disorders, BBB integrity is compromised. GC treatment has been demonstrated to improve the tightness of the BBB. The responses and effects of GCs are mediated by the ubiquitous GC receptor (GR). Ligand-bound GR recognizes and binds to the GC response element located within the promoter region of target genes. Transactivation of certain target genes leads to improved barrier properties of endothelial cells. In this review, we deal with the role of GCs in endothelial cell barrier function. First, we describe the mechanisms of GC action at the molecular level. Next, we discuss the regulation of the BBB by GCs, with emphasis on genes targeted by GCs such as occludin, claudins and VE-cadherin. Finally, we present currently available GC therapeutic strategies and their limitations.
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影响因子：
7.8
作者：
Citi, S
通讯作者：
Citi, S
通过表达突变型紧密连接膜蛋白，细胞旁通透性和跨上皮电阻的功能性分离以及顶端-基底外侧膜内扩散屏障的破坏。
影响因子：
7.8
作者：
Balda, M S;Whitney, J A;Flores, C;Gonzalez, S;Cereijido, M;Matter, K
通讯作者：
Matter, K
影响因子：
20.3
作者：
Erlacher, M;Michalak, EM;Villunger, A
通讯作者：
Villunger, A
影响因子：
56.9
作者：
EVANS, RM
通讯作者：
EVANS, RM
影响因子：
5.8
作者：
Blecharz, Kinga G.;Haghikia, Aiden;Foerster, Carola Y.
通讯作者：
Foerster, Carola Y.