cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.
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DOI:
10.1002/hep.29789
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发表时间:
2018-07
期刊:
Hepatology (Baltimore, Md.)
影响因子:
--
通讯作者:
Theise N
Theise N
中科院分区:
其他
文献类型:
--
作者:
Brunt E;Aishima S;Clavien PA;Fowler K;Goodman Z;Gores G;Gouw A;Kagen A;Klimstra D;Komuta M;Kondo F;Miksad R;Nakano M;Nakanuma Y;Ng I;Paradis V;Nyun Park Y;Quaglia A;Roncalli M;Roskams T;Sakamoto M;Saxena R;Sempoux C;Sirlin C;Stueck A;Thung S;Tsui WMS;Wang XW;Wee A;Yano H;Yeh M;Zen Y;Zucman-Rossi J;Theise N

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具有肝细胞和胆管细胞分化的原发性肝癌被称为“联合(或混合)肝细胞-胆管癌”。这些肿瘤,虽然描述了100多年前,最近吸引了更多的关注,因为在可能的干细胞起源的兴趣,也许是因为更大的频率和临床识别。目前,由于文献中缺乏通用术语,有效的治疗和可预测的结局数据一直难以积累。这篇文章代表了一个共识文件,从病理学家,放射科医生和临床医生的国际社会谁研究和报告这些肿瘤,并建议一个工作术语的诊断和研究方法,以进一步研究和评估。建议诊断是基于常规的组织病理学与苏木精和伊红(H&E);免疫染色是支持,但不是必要的诊断。(肝脏病学2018; 00:000-000)。
Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as “combined (or mixed) hepatocellular-cholangiocarcinoma.” These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation. It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (HEPATOLOGY 2018; 00:000-000).
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