Magnetic-field-assisted electrospinning of aligned straight and wavy polymeric nanofibers.

Magnetic-field-assisted electrospinning of aligned straight and wavy polymeric nanofibers.
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DOI:
10.1002/adma.200903870
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发表时间:
2010-06-11
期刊:
影响因子:
29.4
通讯作者:
Yang, Hong
Yang, Hong
中科院分区:
材料科学1区
文献类型:
--
作者:
Liu, Yaqing;Zhang, Xinping;Xia, Younan;Yang, Hong

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静电纺丝已经成为一种非常有吸引力的方法来制造纳米(nm)和亚微米尺寸的纤维。[1-6]使用静电纺丝技术产生的纳米纤维已经被探索用于广泛的应用,例如组织工程和生物测定,[5,7-13]传感,[14,15]纺织品,[16]过滤,[17]电极,[18]和催化剂载体。[19]在许多这些情况下,控制纤维的排列和排列的能力对于实现设计的功能是至关重要的,特别是对于需要以引导方式释放蛋白质和生长因子的组织工程。[20-22]近年来,通过优化静电纺丝条件,已经实现了纤维质量的改善,并且可以使用旋转收集器或图案化电极来生产定向纤维阵列。[1,23-26]此外,当磁性纳米颗粒与聚合物混合时,也可以制造对齐的纤维。[27]尽管有这些进步,但非常需要开发一种方法,其不仅能够产生良好排列的纳米纤维,而且还允许将所制备的纤维基质方便地沉积到固体基底的表面上,用于器件制造或后续使用。[28]为了产生电纺纤维的对齐或图案化束,已经使用了平行和/或以具有间隙的特定角度布置的电极。[1,23,29,30]当这两种技术相结合时,纤维可以在产品中以改进的顺序纺丝。[24大面积的良好对准的厚纤维层难以使用当前现有的方法来生产。在不分支的情况下控制纤维直径、均匀性和取向也难以同时实现。在这次交流中,我们表明,通过在集电极区适当地引入外部磁场,
Electrospinning has emerged as a very attractive approach to the fabrication of nanometer (nm)-and submicron-sized fibers.[1–6] Nanofibers generated using the electrospinning technique have been explored for a wide range of applications such as tissue engineering and bioassay,[5, 7–13] sensing,[14, 15] textile,[16] filtration,[17] electrode,[18] and catalyst supports.[19] In many of these cases, the ability to control the alignment and arrangement of fibers is critical to achieve the designed functions, particularly for tissue engineering that requires the release of proteins and growth factors in a guided fashion.[20–22] Improvements in fiber quality has been achieved in recent year through the optimization of electrospinning conditions and oriented fiber arrays can be produced using either rotating collectors or patterned electrodes.[1, 23–26] Furthermore, when magnetic nanoparticles are mixed with polymers, aligned fibers can also be fabricated.[27]Despite these advancement, it is highly desirable to develop an approach that is able to not only generate well-aligned nanofibers, but also allow convenient deposition of the as-made fibrous matrices onto surfaces of solid substrates for device fabrication or subsequent uses.[28] To create aligned or patterned bundles of electrospun fibers, electrodes either in parallel and/or arranged at a particular angle with a gap have been used.[1, 23, 29, 30] When these two techniques are combined, fibers can be spun with improved orders in the products.[24, 31] Well-aligned thick fibrous layers in large areas are hard to produce using currently existing approaches. Control of fiber diameter, uniformity, and orientation without branching is also hard to achieve simultaneously. In this communication, we show that by introducing properly an external magnetic field at the collector region, electrospinning of well-ordered
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