Effects of short-term continuous subcutaneous insulin infusion on fasting plasma fibroblast growth factor-21 levels in patients with newly diagnosed type 2 diabetes mellitus.
Effects of short-term continuous subcutaneous insulin infusion on fasting plasma fibroblast growth factor-21 levels in patients with newly diagnosed type 2 diabetes mellitus.
复制标题
DOI：
10.1371/journal.pone.0026359
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Yang M;Dong J;Liu H;Li L;Yang G
探讨短期持续皮下胰岛素输注（CSII）对初诊2型糖尿病（nT 2DM）患者血浆成纤维细胞生长因子-21（FGF-21）水平的影响。68例nT 2DM患者（nT 2DM组）和52例性别、年龄和体重指数（BMI）匹配的正常葡萄糖耐量（NGT组）对照参与了研究。30例FBG≥14.0 mmol/L的nT 2DM患者接受CSII治疗2周，并在治疗前后进行正常血糖-高胰岛素钳夹试验。用商业ELISA试剂盒测量血浆FGF-21浓度。分析血浆FGF-21水平与代谢参数之间的关系。nT 2 DM组空腹血浆FGF-21水平高于NGT组（1.60±0.08 vs. 1.13±0.26 µg/L，P<0.01）。在nT 2DM患者中，CSII治疗2周后空腹血浆FGF-21浓度显著降低（1.60±0.08 vs.1.30±0.05 µg/L，P<0.05），同时全身葡萄糖摄取（M值）和血糖控制显著增加。血浆FGF-21水平（ΔFGF-21）的变化与M值变化所示的胰岛素抵抗改善呈正相关。血浆FGF-21水平与全身胰岛素敏感性相关，并在短期CSII治疗后显著降低。
To investigate the effects of short-term continuous subcutaneous insulin infusion (CSII) on plasma fibroblast growth factor-21 (FGF-21) levels in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). Sixty-eight patients with nT2DM (nT2DM group), and 52 gender-, age- and body mass index (BMI) -matched normal glucose tolerance (NGT group) controls participated in the study. 30 nT2DM patients with FBG≥14.0 mmol/L were treated with CSII for 2 weeks, and were underwent a euglycemic–hyperinsulinemic clamp pre- and post-treatment. Plasma FGF-21 concentrations were measured with a commercial ELISA kit. The relationship between plasma FGF-21 levels and metabolic parameters was also analyzed. Fasting plasma FGF-21 levels were higher in the nT2DM group than in NGT groups (1.60±0.08 vs. 1.13±0.26 µg/L, P<0.01). In nT2DM patients, fasting plasma FGF-21 concentrations were significantly decreased after CSII treatment for 2 weeks (1.60±0.08 vs.1.30±0.05 µg/L, P<0.05), accompanied by a significant increase in the whole body glucose uptake (M value) and blood glucose control. The changes in plasma FGF-21 levels (ΔFGF-21) were positively associated with the amelioration of insulin resistance shown by the changes in M value. Plasma FGF-21 level is associated with whole body insulin sensitivity and significantly reduced following short-term CSII treatment.
登录
查看更多内容
DOI：
10.1016/j.bbrc.2007.06.068
发表时间：
2007-08-24
影响因子：
3.1
作者：
Lundasen, Thomas;Hunt, Mary C.;Rudling, Mats
通讯作者：
Rudling, Mats
影响因子：
5.3
作者：
Goetz, Regina;Beenken, Andrew;Mohammadi, Moosa
通讯作者：
Mohammadi, Moosa
影响因子：
7.7
作者：
Xu J;Lloyd DJ;Hale C;Stanislaus S;Chen M;Sivits G;Vonderfecht S;Hecht R;Li YS;Lindberg RA;Chen JL;Jung DY;Zhang Z;Ko HJ;Kim JK;Véniant MM
通讯作者：
Véniant MM
影响因子：
29
作者：
Badman, Michael K.;Pissios, Pavlos;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria
影响因子：
5.8
作者：
Dostalova, Ivana;Kavalkova, Petra;Haluzik, Martin
通讯作者：
Haluzik, Martin