Interleukin-15 induces antimicrobial activity after release by Cryptococcus neoformans-stimulated monocytes.
Interleukin-15 induces antimicrobial activity after release by Cryptococcus neoformans-stimulated monocytes.
复制标题
Interleukin-15 在被新型隐球菌刺激的单核细胞释放后可诱导抗菌活性。
DOI：
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发表时间：
1998
影响因子：
6.4
通讯作者：
C. Wood
中科院分区：
文献类型：
--
作者：
Christopher H. Mody;Jason C. L. Spurrell;C. Wood
一种新描述的细胞因子，白细胞介素（IL）-15，与IL-2共享许多活动，然而，对IL-15释放的刺激知之甚少，其在抗微生物宿主防御中的作用以前也没有得到证实。这项研究发现，新生隐球菌是一个有效的刺激释放的生物活性IL-15从单核细胞。IL-15和IL-2对淋巴细胞增殖和淋巴细胞介导的抗囊泡和无囊泡C.新人类IL-15恢复了淋巴细胞增殖和抗隐球菌活性，这些活性已被阻断IL-2所废除。IL-15还增强了淋巴细胞的抗隐球菌活性，但不增强单核细胞的活性。这表明IL-15和IL-2在体外协同淋巴细胞活化和增殖，并证明IL-15可以诱导抗微生物活性。总的来说，这些数据表明微生物，特别是C。新生儿是IL-15的重要刺激物，并且IL-15可能在诱导抗微生物效应机制中具有重要作用。
A newly described cytokine, interleukin (IL)-15, shares many activities with IL-2; however, little is known about the stimuli for release of IL-15, and its role in antimicrobial host defense has not previously been demonstrated. This study found that Cryptococcus neoformans is a potent stimulus for the release of biologically active IL-15 from monocytes. Both IL-15 and IL-2 made significant contributions to lymphocyte proliferation and lymphocyte-mediated anticryptococcal activity to encapsulated and acapsular C. neoformans. IL-15 restored lymphocyte proliferation and anticryptococcal activity that had been abrogated by blocking IL-2. IL-15 also enhanced the anticryptococcal activity of lymphocytes but did not enhance the activity of monocytes. This suggests that IL-15 and IL-2 cooperate for lymphocyte activation and proliferation in vitro and demonstrates that IL-15 can induce antimicrobial activity. Taken together, these data suggest that microbes, and in particular C. neoformans, are an important stimulus for IL-15 and that IL-15 may have an important role in induction of antimicrobial effector mechanisms.
白细胞介素 15 激活抗原诱导的淋巴细胞增殖，而白细胞介素 2 没有促有丝分裂作用，可诱导人类免疫缺陷病毒 1 表达。
DOI：
10.1172/jci118831
发表时间：
1996
期刊：
The Journal of clinical investigation.
影响因子：
--
作者：
Patki,AH;Quinones-Mateu,ME;Dorazio,D;Yen-Lieberman,B;Boom,WH;Thomas,EK;Lederman,MM
通讯作者：
Lederman,MM
影响因子：
4.4
作者：
G. Huffnagle;R. Strieter;T. Standiford;R. McDonald;M. Burdick;S. Kunkel;G. Toews
通讯作者：
G. Huffnagle;R. Strieter;T. Standiford;R. McDonald;M. Burdick;S. Kunkel;G. Toews