Localized spectroscopy from anatomically matched compartments: improved sensitivity and localization for cardiac 31P MRS in humans.
Localized spectroscopy from anatomically matched compartments: improved sensitivity and localization for cardiac 31P MRS in humans.
复制标题
来自解剖匹配室的局部光谱：提高人类心脏 31P MRS 的灵敏度和定位。
DOI：
10.1006/jmre.1998.1497
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发表时间：
1998
影响因子：
2.2
通讯作者：
M. von Kienlin
中科院分区：
文献类型：
--
作者：
Ralf Löffler;Rolf Sauter;Heinrich Kolem;Axel Haase;M. von Kienlin
一些开创性的研究表明，人类心脏的局部31P核磁共振波谱可能成为心脏病学的重要诊断工具。主要的限制是由于这些实验的低灵敏度，只允许粗糙的空间分辨率。我们在临床仪器上实现了一个三维版本的SLOOP（“具有最优点扩展函数的光谱定位”）。SLOOP利用所有可用的先验信息，将敏感体积的大小和形状与被检查对象的解剖结构相匹配。因此，与ISIS或化学位移成像（CSI）等传统技术相比，SLOOP减少了邻近器官的污染，提高了灵敏度。最初的研究是在6名健康志愿者身上进行的，温度为1.5 t。良好的定位特性证明了心脏光谱中血液没有共振，肝脏的无pcr光谱也证明了这一点。与传统的CSI相比，单回路心脏光谱的信噪比提高了约30%。考虑表面线圈非均匀B1场中激发角的变化，SLOOP模型计算空间中每一点的局部自旋饱和度。因此，局部光谱的定量评价不需要全局饱和校正。在本研究中，我们发现左心室壁PCr/ γ - atp比值为1.90 +/- 0.33（平均值+/-标准差）。
Several pioneering studies have demonstrated that localized 31P NMR spectroscopy of the human heart might become an important diagnostic tool in cardiology. The main limitation is due to the low sensitivity of these experiments, allowing only crude spatial resolution. We have implemented a three-dimensional version of SLOOP ("spectral localization with optimal pointspread function") on a clinical instrument. SLOOP takes advantage of all available a priori information to match the size and the shape of the sensitive volumes to the anatomical structures in the examined subject. Thus, SLOOP reduces the contamination from adjacent organs and improves the sensitivity compared to conventional techniques such as ISIS or chemical shift imaging (CSI). Initial studies were performed on six healthy volunteers at 1.5 T. The good localization properties are demonstrated by the absence of resonances from blood in the heart spectra, and by PCr-free spectra from the liver. Compared to conventional CSI, the signal-to-noise ratio of the SLOOP heart spectra was improved by approximately 30%. Taking into account the varying excitation angle in the inhomogeneous B1 field of the surface coil, the SLOOP model computes the local spin saturation at every point in space. Therefore, no global saturation correction is required in the quantitative evaluation of local spectra. In this study, we found a PCr/gamma-ATP ratio in the left ventricular wall of 1.90 +/- 0.33 (mean +/- standard deviation).
全身性心肌疾病患者体内磷 31 光谱成像。
DOI：
10.1016/0002-9149(90)90331-t
发表时间：
1990
期刊：
The American journal of cardiology
影响因子：
--
作者：
Schaefer,S;Gober,JR;Schwartz,GG;Twieg,DB;Weiner,MW;Massie,B
通讯作者：
Massie,B
冠状动脉疾病患者等长运动期间高能磷酸盐的局部心肌代谢。
DOI：
10.1056/nejm199012063232304
发表时间：
1990
期刊：
The New England journal of medicine
影响因子：
--
作者：
Weiss,RG;Bottomley,PA;Hardy,CJ;Gerstenblith,G
通讯作者：
Gerstenblith,G