In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial disease.
In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial disease.
复制标题
全身性心肌疾病患者体内磷 31 光谱成像。
DOI：
10.1016/0002-9149(90)90331-t
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Massie,B
中科院分区：
文献类型：
--
作者：
Schaefer,S;Gober,JR;Schwartz,GG;Twieg,DB;Weiner,MW;Massie,B
本研究的目的是确定利用P-31核磁共振波谱技术能否无创地检测扩张型心肌病和左心室肥厚患者的磷代谢异常，以及是否可以根据使用该技术获得的参数来区分这些患者组。对17例患者和14例对照组进行了核磁共振波谱研究。光谱是使用三维光谱成像作为定位技术从静息的人体心脏获得的。使用2特斯拉成像和光谱分析单元在26.3分钟内获得平均体积为48毫升的数据。正常组肌酸/三磷酸腺苷比值为0.89±0.08(均值±标准误)，扩张型心肌病组和左室肥厚组差异无统计学意义。扩张型心肌病患者的磷酸二酯区出现明显的峰值，其磷酸二酯/磷酸肌酸(1.28±0.35)和磷酸二酯/三磷酸腺苷(0.79±0.18)的比值显著高于正常对照组(分别为0.33±0.08和0.29±0.08)。然而，根据光谱模式不能可靠地区分不同的患者组。这些研究证明了在心肌疾病患者中进行磷-31核磁共振成像的可行性。初步结果表明，在静息状态下，严重的全身性心肌病或肥厚患者的磷酸肌酸/三磷酸腺苷的比例没有持续的变化。在一些扩张型心肌病患者中，磷二酯升高，这一发现可能是这种情况下磷脂代谢异常的标志。
The goals of this study were to determine whether abnormalities in phosphorus metabolism could be noninvasively detected using phosphorus-31 nuclear magnetic resonance spectroscopy in patients with dilated cardiomyopathy and left ventricular hypertrophy, and whether these patient groups could be distinguished from each other based on parameters obtained using this technique. Seventeen patients and 14 control subjects were studied using nuclear magnetic resonance spectroscopy. Spectra were obtained from the human heart at rest using 3-dimensional spectroscopic imaging as a localization technique. Data were acquired over an average volume of 48 cc in 26.3 minutes using a 2 tesla imaging and spectroscopy unit. The ratio of phosphocreatine to adenosine triphosphate was 0.89 ± 0.08 (mean ± standard error) in normal subjects and did not differ significantly in patients with dilated cardiomyopathy or left ventricular hypertrophy. A prominent peak in the phosphodiester region was seen much more frequently in patients with dilated cardiomyopathy, resulting in significantly higher ratios of phosphodiester to phosphocreatine (1.28 ± 0.35) and phosphodiester to adenosine triphosphate (0.79 ± 0.18) in this group compared to normal subjects (0.33 ± 0.08 and 0.29 ± 0.08, respectively). However, the various patient groups could not be reliably distinguished from each other based on spectral patterns.These studies demonstrate the feasibility of performing phosphorus-31 nuclear magnetic resonance spectroscopic imaging in patients with myocardial disease. The initial results indicate that, under resting conditions, the ratio of phosphocreatine to adenosine triphosphate is not consistently altered in patients with severe global cardiomyopathies or hypertrophy. Phosphodiesters are elevated in some patients with dilated cardiomyopathy, a finding that may signify abnormal phospholipid metabolism in this condition.
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作者：
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DOI：
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DOI：
--
发表时间：
1975
期刊：
影响因子：
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作者：
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