Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study.
Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study.
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DOI：
10.1186/1742-6405-9-32
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发表时间：
2012-10-26
影响因子：
2.2
通讯作者：
Maartens G
中科院分区：
文献类型：
--
作者：
Sinxadi PZ;McIlleron HM;Dave JA;Smith PJ;Levitt NS;Maartens G
血脂异常和血脂异常与利托那韦增强的蛋白酶抑制剂暴露相关。洛匹那韦/利托那韦是资源有限环境中最常用的蛋白酶抑制剂，通常会导致血脂异常。关于洛匹那韦浓度与脂质变化之间的相关性，存在相互矛盾的数据。研究南非HIV感染成人的血浆洛匹那韦浓度与血脂和血糖浓度之间的关系。参与者稳定基于洛匹那韦的抗逆转录病毒治疗被纳入一项横断面研究。空腹过夜后，测量总胆固醇、甘油三酯和洛匹那韦浓度，并进行口服葡萄糖耐量试验。回归分析用于确定血浆洛匹那韦浓度与空腹和2小时血糖、空腹胆固醇和甘油三酯浓度之间的相关性。共有84名参与者（72名女性），中位年龄为36岁。中位血压、体重指数和腰臀比分别为108/72 mmHg、26 kg/m2和0.89。中位CD 4计数为478个细胞/mm 3。洛匹那韦治疗的中位持续时间为18.5个月。中位（四分位距）洛匹那韦浓度为8.0（5.2 - 12.8）μg/mL。回归分析显示，洛匹那韦给药前浓度与空腹胆固醇之间无显著相关性（β系数−0.04（95% CI −0.07至0.00）），甘油三酯（β系数−0.01（95% CI −0.04至0.02）），空腹血糖（β系数−0.01（95% CI −0.04至0.02））或2小时葡萄糖浓度（β系数−0.02（95% CI −0.09至0.06））。洛匹那韦浓度高于中位数与血脂异常或血脂异常的存在无关。洛匹那韦血浆浓度与血脂和血糖浓度之间无相关性。
Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. There are contradictory data regarding the association between lopinavir concentrations and changes in lipids. To investigate associations between plasma lopinavir concentrations and lipid and glucose concentrations in HIV-infected South African adults. Participants stable on lopinavir-based antiretroviral therapy were enrolled into a cross-sectional study. After an overnight fast, total cholesterol, triglycerides, and lopinavir concentrations were measured and an oral glucose tolerance test was performed. Regression analyses were used to determine associations between plasma lopinavir concentrations and fasting and 2 hour plasma glucose, fasting cholesterol, and triglycerides concentrations. There were 84 participants (72 women) with a median age of 36 years. The median blood pressure, body mass index and waist: hip ratio were 108/72 mmHg, 26 kg/m2 and 0.89 respectively. The median CD4 count was 478 cells/mm3. Median duration on lopinavir was 18.5 months. The median (interquartile range) lopinavir concentration was 8.0 (5.2 to 12.8) μg/mL. Regression analyses showed no significant association between lopinavir pre-dose concentrations and fasting cholesterol (β-coefficient −0.04 (95% CI −0.07 to 0.00)), triglycerides (β-coefficient −0.01 (95% CI −0.04 to 0.02)), fasting glucose (β-coefficient −0.01 (95% CI −0.04 to 0.02)), or 2-hour glucose concentrations (β-coefficient −0.02 (95% CI −0.09 to 0.06)). Lopinavir concentrations above the median were not associated with presence of dyslipidaemia or dysglycaemia. There was no association between lopinavir plasma concentrations and plasma lipid and glucose concentrations.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
4.9
作者：
De Requena, DG;Blanco, F;Soriano, V
通讯作者：
Soriano, V
DOI：
10.1097/00126334-200308150-00007
发表时间：
2003-08-15
影响因子：
3.6
作者：
Gutiérrez, F;Padilla, S;Martin-Hidalgo, A
通讯作者：
Martin-Hidalgo, A
影响因子：
16.2
作者：
De Wit, Stephane;Sabin, Caroline A.;Phillips, Andrew
通讯作者：
Phillips, Andrew
影响因子：
4.9
作者：
Decloedt, Eric H.;McIlleron, Helen;Maartens, Gary
通讯作者：
Maartens, Gary