Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading.
Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading.
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人体脱氢抗坏血酸的维生素 C 活性——口服负荷后血液维生素 C 浓度或尿液排泄变化之间的关联。
DOI：
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发表时间：
2008
影响因子：
1.6
通讯作者：
Y. Kagawa
中科院分区：
文献类型：
--
作者：
M. Tsujimura;Shizu Higasa;Kazuhiro Nakayama;Y. Yanagisawa;S. Iwamoto;Y. Kagawa
我们对摄入低维生素C（C）（C ≤ 5 mg/d）饮食3 d的受试者进行了阿萨或D阿萨（1 mmol）的口服负荷，并测定了尿和血维生素C。由于采用交叉方法，因此在每名受试者中间隔约1个月后重复相同的实验。2005年和2006年共有17名受试者参加的实验结果如下。(1)有显着的尿C排泄的个体差异。(2)C负荷后24小时尿中的C水平在两种口服C形式（阿萨和D阿萨）之间没有差异。(3)D阿萨组在C负荷后0 - 3 h的C排泄量显著较高（p<0.05），而阿萨组在C负荷后3 - 6、6 - 9、9 - 12和12 - 24 h的C排泄量显著较高（p<0.05或p<0.01）。(4)D阿萨组的血C浓度和C负荷后1 h的C增量显著高于阿萨组（分别为p<0.05和p<0.01）。(5)对C代谢与谷胱甘肽S-转移酶P（GSTP）1-1单核苷酸多态性之间的关联进行评估，结果显示，与AA纯合子相比，GA杂合子在阿萨负荷后尿C排泄量和24 h尿C水平显著降低（p <0.05），而在D阿萨负荷后0 - 3 h尿C排泄量显著降低（p<0.05）。考虑到C在人体中作为D阿萨的活性，基于单次加载C后的尿液和血液C水平，尽管代谢周转时间不同，但D阿萨的利用率与阿萨相当。还阐明了外源性物质代谢酶GSTP 1 -1多态性参与碳代谢，特别是尿碳排泄。这表明，在确定个人的C需求量考虑基因多态性的必要性。这篇论文的摘要由维生素C研究委员会（御茶水大学）于2007年报道。
We performed oral loading of AsA or DAsA (1 mmol) in subjects who had consumed a diet low in vitamin C (C) (C< or =5 mg/d) for 3 d before loading, and measured urinary and blood vitamin C. Since the crossover method was used, the same experiment was repeated after an interval of about 1 mo in each subject. The results of the experiment including a total of 17 subjects for 2005 and 2006, were as follows. (1) There were marked individual differences in urinary C excretion. (2) The C level in 24-h urine after C loading did not differ between the two orally administered C forms (AsA and DAsA). (3) C excretion between 0 and 3 h after C loading was significantly higher (p<0.05) for the DAsA group, while those between 3 and 6, 6 and 9, 9 and 12, and 12 and 24 h after C loading were significantly higher (p<0.05 or p<0.01) for the AsA group. (4) The blood C concentration and the increase in C 1 h after C loading were significantly higher (p<0.05 and p<0.01, respectively) in the DAsA than in the AsA group. (5) Evaluation of the association between C metabolism and the single nucleotide polymorphisms of glutathione S-transferase P (GSTP) 1-1 showed a lower urinary C excretion and a significantly lower C level in 24-h urine (p<0.05) after AsA loading, and a significantly lower urinary C excretion between 0 and 3 h after DAsA loading (p<0.05) for the GA heterozygotes than for the AA homozygotes. Considering the activity of C as DAsA in humans, based on urinary and blood C levels after a single loading of C, the utilization of DAsA is equivalent to that of AsA, although the metabolic turnover time is different. The involvement of polymorphisms in the xenobiotic metabolizing enzyme, GSTP1-1, in C metabolism, particularly urinary C excretion, was also clarified. This demonstrates the necessity of considering gene polymorphisms in determining individual C requirements. An abstract of this paper was reported by the Vitamin C Research Committee (Ochanomizu University) in 2007.
抗坏血酸的肾脏排泄：年龄和性别的影响。
影响因子：
3.5
作者：
Oreopoulos,DG;Lindeman,RD;VanderJagt,DJ;Tzamaloukas,AH;Bhagavan,HN;Garry,PJ
通讯作者：
Garry,PJ