miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis.
miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis.
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DOI：
10.7150/jca.2.67
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发表时间：
2011-02-07
影响因子：
3.9
通讯作者：
Merino MJ
中科院分区：
文献类型：
--
作者：
Walter BA;Gómez-Macias G;Valera VA;Sobel M;Merino MJ
Aims: microRNAs (miRNAs) are a class of small noncoding RNAs that can act as key modulators in tumorigenesis-related genes. Specifically, it has been suggested that miR-21 overexpression plays a role in the development and progression of breast cancer. So far, the role of miRNAs in pregnancy-associated breast cancer (PABC) has not been investigated. Methods and Results: We evaluated miR-21 expression by quantitative RT-PCR in 35 patients, 25 with PABC and 10 control breast cancer cases not pregnancy-associated with similar clinicopathological features. We then analyzed protein expression for PTEN, BCL2 and PDCD4 as miR-21 target genes by IHC, and finally correlated the results with patients' clinicopathological features. Significant overexpression of miR-21 in PABC tumors compared to normal adjacent tissue was found. Overexpression of miR-21 was frequently found in high grade tumors with loss of hormone receptor expression and was significantly associated with positive lymph nodes (p=0.025). In PABC patients, PTEN, BCL2 and PDCD4 target protein expression was decreased in 80%, 76% and 40% respectively. Conclusion: Our study supports the involvement of miR-21 in breast cancer progression and metastasis formation in PABC implying a role of this miRNA as a marker for poor prognosis in PABC patients.
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Golub, TR
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