Co-administration of GnRH-agonist and hCG for final oocyte maturation (double trigger) in patients with low number of oocytes retrieved per number of preovulatory follicles--a preliminary report.
Co-administration of GnRH-agonist and hCG for final oocyte maturation (double trigger) in patients with low number of oocytes retrieved per number of preovulatory follicles--a preliminary report.
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DOI：
10.1186/1757-2215-7-77
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发表时间：
2014-08-02
影响因子：
4
通讯作者：
Orvieto R
中科院分区：
文献类型：
--
作者：
Haas J;Zilberberg E;Dar S;Kedem A;Machtinger R;Orvieto R
最近，联合给予GnRH激动剂和hCG分别用于OPU前40和34小时的最终卵母细胞成熟（双触发）被建议作为真正空卵泡综合征的治疗。在本研究中，我们的目的是评估双触发器是否能提高排卵前卵泡获卵率低（<50%）患者的获卵率。在这项概念验证队列历史研究中，我们比较了8个IVF周期的刺激特征，其中包括患者既往IVF尝试的双触发，仅用hCG触发。与之前的周期（仅hCG触发）相比，接受双触发的患者（研究组）在hCG给药当天获得的卵母细胞数量、2 PN数量、移植的胚胎数量以及获得的卵母细胞数量与直径>10 mm和>14 mm的卵泡数量的比例显著更高，TQE数量倾向于更高。在研究组中记录了3例正在进行的临床妊娠，而在仅hCG触发组中没有记录。在OPU前40和34小时分别联合给予GnRH激动剂和hCG用于最终卵母细胞成熟（双触发），被认为是治疗低/低卵母细胞产量患者的一种有价值的新工具，尽管卵泡发育和E2水平明显正常，并且在OPU当天存在最佳hCG水平。
Recently, the co-administration of GnRH agonist and hCG for final oocyte maturation- 40 and 34 hours prior to OPU, respectively (double trigger) was suggested as the treatment of genuine empty follicle syndrome. In the present study, we aim to evaluate whether the double trigger improves the number of oocytes retrieved in patients with low (<50%) number of oocytes retrieved per number of preovulatory follicles. In this proof of concept cohort historical study, we compared the stimulation characteristics of 8 IVF cycles, which include the double trigger to the patients’ previous IVF attempt, triggered with hCG-only. Patients who received the double trigger (study group) had a significantly higher number of oocytes retrieved, number of 2PN, number of embryos transferred and significantly higher proportions of the number of oocytes retrieved to the number of follicles >10 mm and >14 mm in diameter on day of hCG administration, with a tendency toward a higher number of TQE, as compared to their previous cycles (hCG-only trigger). Three ongoing clinical pregnancies were recorded in the study group and none in the hCG-only trigger group. Co-administration of GnRH-agonist and hCG for final oocyte maturation, 40 and 34 hours prior to OPU, respectively (double trigger), is suggested as a valuable new tool in the armamentarium for treating patients with low/poor oocytes yield despite an apparently normal follicular development and E2 levels and in the presence of optimal hCG levels on the day of OPU.
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影响因子：
6.7
作者：
Mesen, Tolga B.;Yu, Bo;Richter, Kevin S.;Widra, Eric;DeCherney, Alan H.;Segars, James H.
通讯作者：
Segars, James H.
影响因子：
4
作者：
Orvieto R
通讯作者：
Orvieto R
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作者：
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通讯作者：
Penzias, AS
影响因子：
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作者：
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影响因子：
6.1
作者：
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