Ovarian hyperstimulation syndrome- an optimal solution for an unresolved enigma.

Ovarian hyperstimulation syndrome- an optimal solution for an unresolved enigma.
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DOI:
10.1186/1757-2215-6-77
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发表时间:
2013-11-05
影响因子:
4
通讯作者:
Orvieto R
Orvieto R
中科院分区:
医学3区
文献类型:
--
作者:
Orvieto R

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卵巢过度刺激综合征(OHSS)是控制性超排卵(COH)的严重并发症。该综合征几乎总是在易感患者给予hCG后或妊娠早期出现。尽管有多年的临床经验,除了抑制hCG的排卵诱导触发外,还没有完全预防严重OHSS的精确方法。近年来,促性腺激素释放激素(GnRH)拮抗剂联合促性腺激素释放激素(GnRH)激动剂的促性腺激素释放激素(COH)已成为消除早期重度OHSS的常用手段。然而,观察到的植入率和妊娠率下降,鼓励不同的修改黄体支持,旨在改善结果。建议的方法之一是1500 IU hCG黄体拯救,这似乎是一个有前途的协议,旨在减少(而不是消除)严重的早期OHSS,而不影响结果。在本文中,我们讨论了不同的建议策略,并提供了一个严格的分流,旨在消除严重OHSS的发生的基础上,几个临床观察,包括促性腺激素释放激素拮抗剂在COH协议的作用,使用不同的黄体拯救协议和能力,在囊胚期胚胎移植。
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation (COH). The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, there are no precise methods to completely prevent severe OHSS, except by withholding the ovulation-inducing trigger of hCG. Recently, COH which combining GnRH antagonist co-treatment and GnRH agonist trigger has become a common tool aiming to eliminate severe early OHSS. However, the observed decrease in implantation and pregnancy rates following this approach has encouraged different modifications of luteal support aiming to improve outcome. One of the suggest approach is the 1500 IU hCG luteal rescue, which appears to be a promising protocol, aiming to reduce (rather than eliminating) severe early OHSS, without compromising outcome. In the present paper we discuss the different suggested strategies and offer a strict triage, aimed at eliminating the occurrence of severe OHSS based on several clinical observations, including the role of GnRH-antagonist in COH protocols, the use of different luteal rescue protocols and the ability to transfer embryos in the blastocyst stage.
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