The effects of RNA editing in cancer tissue at different stages in carcinogenesis.
The effects of RNA editing in cancer tissue at different stages in carcinogenesis.
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DOI：
10.1080/15476286.2021.1877024
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发表时间：
2021-11
期刊：
影响因子：
4.1
通讯作者：
Marek-Trzonkowska N
中科院分区：
文献类型：
--
作者：
Kurkowiak M;Arcimowicz Ł;Chruściel E;Urban-Wójciuk Z;Papak I;Keegan L;O'Connell M;Kowalski J;Hupp T;Marek-Trzonkowska N
RNA编辑是在正常生理过程中观察到的最普遍和最丰富的转录后RNA修饰形式之一，并且在包括癌症在内的疾病中经常异常。RNA编辑改变了mRNA的序列，使它们与源DNA序列不同。编辑的mRNA可以产生编辑-重新编码的蛋白质同种型，其在功能上不同于相应的基因组编码的蛋白质同种型。哺乳动物中的主要类型的RNA编辑通过双链RNA（dsRNA）内的腺苷酶促脱氨为肌苷（A至I）或前mRNA转录物中的发夹而发生。催化这些过程的酶属于作用于RNA的腺苷脱氨酶（阿达尔）家族。与人类疾病相关的RNA编辑景观的绝大多数知识都是使用体外癌细胞培养模型获得的。然而，这种体外模型的局限性在于，所获得的结果的生理或疾病相关性不一定是明显的。在这篇综述中，我们重点讨论了体内发生的RNA编辑事件，已确定在人类癌症组织中使用手术切除或临床检索患者的样本。我们讨论了体内肿瘤中发生的RNA编辑事件如何识别与人类癌症生理学相关的病理信号传导机制，这些机制与癌症进展的不同阶段有关，包括启动，促进，存活，增殖，免疫逃逸和转移。
RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using in vitro cancer cell culture models. The limitation of such in vitro models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing in vivo occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours in vivo can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.
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影响因子：
56.9
作者：
CHEN, SH;HABIB, G;CHAN, L
通讯作者：
CHAN, L
DOI：
10.1073/pnas.240464097
发表时间：
2000-12-05
影响因子：
11.1
作者：
Brown, BA;Lowenhaupt, K;Rich, A
通讯作者：
Rich, A
影响因子：
16.8
作者：
Bhalla, T;Rosenthal, JJC;Reenan, R
通讯作者：
Reenan, R
影响因子：
12.3
作者：
Blow MJ;Grocock RJ;van Dongen S;Enright AJ;Dicks E;Futreal PA;Wooster R;Stratton MR
通讯作者：
Stratton MR
影响因子：
14.9
作者：
Cesarini V;Silvestris DA;Tassinari V;Tomaselli S;Alon S;Eisenberg E;Locatelli F;Gallo A
通讯作者：
Gallo A